Source:http://linkedlifedata.com/resource/pubmed/id/16340375
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2005-12-12
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pubmed:abstractText |
Since 1992, miniaturized pulsatile air-driven ventricular assist devices (VADs), "Berlin Heart," have been used at many institutions (36 cases in North America in 19 different institutions) for pediatric use. Heparin-induced thrombocytopenia (HIT II) is a significant complication rarely reported in the setting of adult VAD support; no similar report exists concerning pediatric VAD support. We report on a 13-month-old, 8.1 kg girl who required LVAD support for cardiogenic shock of unclear etiology. The patient had a history of multiple surgical repairs for correction of complex congenital heart disease consisting of a series of left heart obstructive lesions (Shone's complex). Despite aggressive ventilatory and inotropic support, the patient continued to deteriorate and subsequently required extracorporeal life support. After 7 days of conventional venoarterial extracorporeal membrane oxygenation, a 10 ml Berlin Heart VAD was implanted. After implantation, the patient developed persistent low-grade fever of unclear etiology, gradual thrombocytopenia, and deterioration of renal function. On postimplant day 10, the pump required replacement because of concerns about an inlet valve thrombus; the explanted device demonstrated a nearly occlusive clot not appreciable from external inspection. Simultaneously, HIT II was diagnosed as a result of hematology workup for persistent thrombocytopenia. We discuss the unique challenges posed by HIT II complicating pediatric VAD support and in relation to the heparin coating of the device.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
1058-2916
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
820-5
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pubmed:dateRevised |
2006-5-23
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pubmed:meshHeading |
pubmed-meshheading:16340375-Anticoagulants,
pubmed-meshheading:16340375-Female,
pubmed-meshheading:16340375-Heart Defects, Congenital,
pubmed-meshheading:16340375-Heart-Assist Devices,
pubmed-meshheading:16340375-Heparin,
pubmed-meshheading:16340375-Humans,
pubmed-meshheading:16340375-Infant,
pubmed-meshheading:16340375-Shock, Cardiogenic,
pubmed-meshheading:16340375-Thrombocytopenia
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pubmed:articleTitle |
Heparin-induced thrombocytopenia complicating support by the Berlin Heart.
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pubmed:affiliation |
Division of Pediatric Cardiothoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Pirooz.Eghtesady@cchmc.org
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pubmed:publicationType |
Journal Article,
Case Reports
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