Linked Life Data

16339790

Source:http://linkedlifedata.com/resource/pubmed/id/16339790

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-1-17
pubmed:abstractText
During normothermic cardiopulmonary bypass (CPB), the effect on propofol pharmacokinetics of changes in its binding to plasma proteins is consistent with the predictions of the well-stirred model of hepatic elimination for nonrestrictively cleared drug. However, whether changes in binding lead to clinically significant changes in the drug effect remains unclear. The purpose of this study was to assess changes in the drug effect of propofol in response to altered plasma binding using quantitative EEG measurements.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0007-0912
pubmed:author
pubmed:issnType
Print
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
179-85
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Changes in the effect of propofol in response to altered plasma protein binding during normothermic cardiopulmonary bypass.
pubmed:affiliation
Department of Anaesthesiology, Saitama Cardiovascular and Pulmonary Centre, 1696 Itai Konan-machi Osato-gun, Saitama 360-0105, Japan.
pubmed:publicationType
Journal Article, Randomized Controlled Trial