Source:http://linkedlifedata.com/resource/pubmed/id/16339539
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
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| pubmed:dateCreated |
2005-12-12
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| pubmed:abstractText |
Fas ligand (FasL) has the potential to induce inflammation accompanied by massive neutrophil infiltration. We previously reported that FasL rapidly induces the production of various inflammatory cytokines including IL-1beta and IL-17. In this study, we investigated the mechanism of the FasL-induced IL-17 production. We found that the culture supernatant of mouse resident peritoneal exudate cells (PEC) cocultured with FasL-expressing tumor (FFL) cells induced IL-17 production in freshly isolated resident PEC. Anti-IL-1beta Ab strongly inhibited the IL-17-inducing activity. However, rIL-1beta by itself induced only weak IL-17 production. Intriguingly, anti-IL-12 Ab but not an IL-15-neutralizing agent, IL15R-Fc, strongly inhibited the FasL-induced IL-17-inducing activity. IL-23, which shares the p40 subunit with IL-12, but not IL-12 itself, induced IL-17 production synergistically with IL-1beta in resident PEC. FasL induced the production of IL-23 in PEC in vivo and in vitro, and IL-17 production following the i.p. injection of FFL cells was severely impaired in p40-/- mice, indicating that IL-23 plays an important role in the FasL-induced IL-17 production. FFL also induced the production of IL-23 in bone marrow- or PEC-derived dendritic cells (DCs). Finally, FasL induced only weak p40 production in a mixture of p40-/- and Fas-/- DC, indicating that FasL induces IL-23 production in DC mainly in a cell-autonomous manner.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/FASLG protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fas Ligand Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Fasl protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/IL23A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Il23a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-17,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-23,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-23 Subunit p19,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factors
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
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| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
175
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
8024-31
|
| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16339539-Animals,
pubmed-meshheading:16339539-Coculture Techniques,
pubmed-meshheading:16339539-Dendritic Cells,
pubmed-meshheading:16339539-Fas Ligand Protein,
pubmed-meshheading:16339539-Humans,
pubmed-meshheading:16339539-Inflammation,
pubmed-meshheading:16339539-Interleukin-1,
pubmed-meshheading:16339539-Interleukin-17,
pubmed-meshheading:16339539-Interleukin-23,
pubmed-meshheading:16339539-Interleukin-23 Subunit p19,
pubmed-meshheading:16339539-Interleukins,
pubmed-meshheading:16339539-Membrane Glycoproteins,
pubmed-meshheading:16339539-Mice,
pubmed-meshheading:16339539-Peritoneum,
pubmed-meshheading:16339539-Tumor Cells, Cultured,
pubmed-meshheading:16339539-Tumor Necrosis Factors
|
| pubmed:year |
2005
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| pubmed:articleTitle |
Fas ligand induces cell-autonomous IL-23 production in dendritic cells, a mechanism for Fas ligand-induced IL-17 production.
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| pubmed:affiliation |
Center for the Development of Molecular Target Drugs, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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