Linked Life Data

16338655

Source:http://linkedlifedata.com/resource/pubmed/id/16338655

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2005-12-12
pubmed:abstractText
Notch signaling has multiple functions during invertebrate and vertebrate development, where it plays important roles in cell fate determination, proliferation, survival, and border formation. The precise function of Notch signaling is context dependent, and one of the unsolved mysteries of Notch signaling is how a relatively stereotyped signal transduction pathway exerts such a wide variety of context-specific responses. Recent data from Gustaffson et al. provide important new information on this topic by showing that hypoxia enhances Notch signaling due to the association of Notch and HIF-1alpha. This interaction may have important consequences for tumor cell growth.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1535-6108
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
435-7
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Lasting longer without oxygen: The influence of hypoxia on Notch signaling.
pubmed:affiliation
Abramson Family Cancer Research Institute, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA. wpear@mail.med.upenn.edu
pubmed:publicationType
Journal Article, Review