rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2005-12-12
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pubmed:abstractText |
Allogeneic stem cell transplantation is a potentially curative therapy for patients with multiple myeloma. Polyclonal antithymocyte globulins (ATG) or monoclonal anti-CD52 (Alemtuzumab) are included in conditioning regimens to enhance engraftment and reduce risk of severe graft-vs-host disease. Because both agents have been reported to induce depletion of B cells, we sought to investigate their cytotoxic activity on myeloma cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal, Humanized,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Antilymphocyte Serum,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Complement System Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/alemtuzumab
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0301-472X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1531-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16338496-Antibodies, Monoclonal,
pubmed-meshheading:16338496-Antibodies, Monoclonal, Humanized,
pubmed-meshheading:16338496-Antibodies, Neoplasm,
pubmed-meshheading:16338496-Antilymphocyte Serum,
pubmed-meshheading:16338496-Apoptosis,
pubmed-meshheading:16338496-Bone Marrow,
pubmed-meshheading:16338496-Caspases,
pubmed-meshheading:16338496-Cell Death,
pubmed-meshheading:16338496-Complement System Proteins,
pubmed-meshheading:16338496-Female,
pubmed-meshheading:16338496-Flow Cytometry,
pubmed-meshheading:16338496-Humans,
pubmed-meshheading:16338496-Male,
pubmed-meshheading:16338496-Multiple Myeloma,
pubmed-meshheading:16338496-Transplantation Conditioning,
pubmed-meshheading:16338496-Tumor Cells, Cultured
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pubmed:year |
2005
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pubmed:articleTitle |
Antithymocyte globulin induces complement-dependent cell lysis and caspase-dependent apoptosis in myeloma cells.
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pubmed:affiliation |
Department of Bone Marrow Transplantation, University Medical Center Hamburg-Eppendorf, Germany. ayuketan@uke.uni-hamburg.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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