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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-1-23
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pubmed:abstractText |
We investigated the circulating cytotoxic CD160+ CD8(high) subset in correlation to antiviral immunity and response to highly active antiretroviral therapy (HAART) in HIV+ subjects. The study included 45 treatment-naive patients receiving HAART for 18 months, retrospectively defined as good (n=29) and transient (n=16) responders. HIV-specific CD8 T lymphocyte levels were measured by IFNgamma production in response to p17 Gag, in the presence of immobilized anti-CD160 mAb. We report a significantly increased baseline level of CD160+ CD8(high) subset in good therapy responders. CD160+ CD8(high) subset correlates with CD4+ T cell count, immune activation, and viral load. CD160+ CD8(high) lymphocytes contain a high amount of Granzyme B and include virus-specific T lymphocytes in HIV-1+ subjects. Co-stimulation through CD160 molecules enhances IFNgamma production in response to p17 Gag. Therefore, the CD160+ CD8(high) subset may be useful for monitoring of virus-specific cellular immunity and predicting response to antiretroviral therapy in chronic HIV-1 infection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/CD160 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/GPI-Linked Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, gag,
http://linkedlifedata.com/resource/pubmed/chemical/Immunodominant Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/env Gene Products, Human...,
http://linkedlifedata.com/resource/pubmed/chemical/p17 gag peptide, human...
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0008-8749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
237
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
96-105
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16337931-Adolescent,
pubmed-meshheading:16337931-Adult,
pubmed-meshheading:16337931-Antigens, CD,
pubmed-meshheading:16337931-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:16337931-Case-Control Studies,
pubmed-meshheading:16337931-Female,
pubmed-meshheading:16337931-GPI-Linked Proteins,
pubmed-meshheading:16337931-Gene Products, gag,
pubmed-meshheading:16337931-HIV Infections,
pubmed-meshheading:16337931-HIV-1,
pubmed-meshheading:16337931-Humans,
pubmed-meshheading:16337931-Immunodominant Epitopes,
pubmed-meshheading:16337931-Immunologic Memory,
pubmed-meshheading:16337931-Interferon-gamma,
pubmed-meshheading:16337931-Lymphocyte Activation,
pubmed-meshheading:16337931-Male,
pubmed-meshheading:16337931-Membrane Proteins,
pubmed-meshheading:16337931-Middle Aged,
pubmed-meshheading:16337931-Peptide Fragments,
pubmed-meshheading:16337931-Receptors, Immunologic,
pubmed-meshheading:16337931-Retrospective Studies,
pubmed-meshheading:16337931-T-Lymphocyte Subsets,
pubmed-meshheading:16337931-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:16337931-env Gene Products, Human Immunodeficiency Virus
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pubmed:year |
2005
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pubmed:articleTitle |
The CD160+ CD8high cytotoxic T cell subset correlates with response to HAART in HIV-1+ patients.
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pubmed:affiliation |
National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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