Linked Life Data

16337591

Source:http://linkedlifedata.com/resource/pubmed/id/16337591

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2005-12-12
pubmed:databankReference
pubmed:abstractText
The muscle A-kinase anchoring protein (mAKAP) tethers cAMP-dependent enzymes to perinuclear membranes of cardiomyocytes. We now demonstrate that two alternatively spliced forms of mAKAP are expressed: mAKAPalpha and mAKAPbeta. The longer form, mAKAPalpha, is preferentially expressed in the brain. mAKAPbeta is a shorter form of the anchoring protein that lacks the first 244 amino acids and is preferentially expressed in the heart. The unique amino terminus of mAKAPalpha can spatially restrict the activity of 3-phosphoinositide-dependent kinase-1 (PDK1). Biochemical and genetic analyses demonstrate that simultaneous recruitment of PDK1 and ERK onto mAKAPalpha facilitates activation and release of the downstream target p90RSK. The assembly of tissue-specific signaling complexes provides an efficient mechanism to integrate and relay lipid-mediated and mitogenic activated signals to the nucleus.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1097-2765
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
661-72
pubmed:dateRevised
2011-4-4
pubmed:meshHeading
pubmed-meshheading:16337591-A Kinase Anchor Proteins, pubmed-meshheading:16337591-Adaptor Proteins, Signal Transducing, pubmed-meshheading:16337591-Alternative Splicing, pubmed-meshheading:16337591-Amino Acid Sequence, pubmed-meshheading:16337591-Animals, pubmed-meshheading:16337591-Cell Line, pubmed-meshheading:16337591-Cloning, Molecular, pubmed-meshheading:16337591-Extracellular Signal-Regulated MAP Kinases, pubmed-meshheading:16337591-Humans, pubmed-meshheading:16337591-Mice, pubmed-meshheading:16337591-Mice, Knockout, pubmed-meshheading:16337591-Molecular Sequence Data, pubmed-meshheading:16337591-Organ Specificity, pubmed-meshheading:16337591-Protein-Serine-Threonine Kinases, pubmed-meshheading:16337591-RNA, Messenger, pubmed-meshheading:16337591-Rats, pubmed-meshheading:16337591-Ribosomal Protein S6 Kinases, 90-kDa
pubmed:year
2005
pubmed:articleTitle
Spatial restriction of PDK1 activation cascades by anchoring to mAKAPalpha.
pubmed:affiliation
Howard Hughes Medical Institute and Vollum Institute, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97239, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, N.I.H., Extramural