rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2005-12-12
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pubmed:abstractText |
Proliferation and IL-2 production in response to T-cell receptor ligation are impaired in patients with Wiskott-Aldrich syndrome (WAS). The transcription factors nuclear factor-kappaB (NF-kappaB), nuclear factor of activated T cells (NF-AT), and activating protein-1 (AP-1) play a critical role in IL-2 gene expression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/NFATC Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-jun,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor AP-1,
http://linkedlifedata.com/resource/pubmed/chemical/Was protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Wiskott-Aldrich Syndrome Protein
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0091-6749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
116
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1364-71
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16337472-Active Transport, Cell Nucleus,
pubmed-meshheading:16337472-Animals,
pubmed-meshheading:16337472-DNA,
pubmed-meshheading:16337472-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:16337472-Interleukin-2,
pubmed-meshheading:16337472-Mice,
pubmed-meshheading:16337472-NF-kappa B,
pubmed-meshheading:16337472-NFATC Transcription Factors,
pubmed-meshheading:16337472-Phosphorylation,
pubmed-meshheading:16337472-Protein Transport,
pubmed-meshheading:16337472-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:16337472-RNA, Messenger,
pubmed-meshheading:16337472-T-Lymphocytes,
pubmed-meshheading:16337472-Transcription Factor AP-1,
pubmed-meshheading:16337472-Wiskott-Aldrich Syndrome,
pubmed-meshheading:16337472-Wiskott-Aldrich Syndrome Protein
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pubmed:year |
2005
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pubmed:articleTitle |
Defective nuclear translocation of nuclear factor of activated T cells and extracellular signal-regulated kinase underlies deficient IL-2 gene expression in Wiskott-Aldrich syndrome.
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pubmed:affiliation |
Division of Immunology, Children's Hospital, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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