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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0027814,
umls-concept:C0031117,
umls-concept:C0033684,
umls-concept:C0034693,
umls-concept:C0035820,
umls-concept:C0036394,
umls-concept:C0079414,
umls-concept:C0185117,
umls-concept:C0258174,
umls-concept:C0443146,
umls-concept:C1167622,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C2349975,
umls-concept:C2911684
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pubmed:issue |
1-2
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pubmed:dateCreated |
2006-2-28
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pubmed:abstractText |
Netrin-1 is a chemotropic factor that plays an important role as a survival factor in the adult nervous system. To investigate whether netrin-1 is involved in autoimmune injury of the peripheral nervous system (PNS), the temporal expression of netrin-1 protein was analyzed in the sciatic nerves of Lewis rats with experimental autoimmune neuritis (EAN). Western blot analysis revealed a significant increase in the level of netrin-1 protein in the sciatic nerves of rats on days 11 to 24 post-immunization (p.i.) compared to controls; netrin-1 expression declined by day 30 p.i. Immunohistochemistry revealed that netrin-1 protein was expressed weakly in Schwann cells and vessels in the sciatic nerves of normal and CFA-immunized control rats. In the sciatic nerves of EAN-affected rats, netrin-1 immunoreactivity was increased mainly in the cell membrane and extracellular matrix of OX42-positive macrophages and S100-positive Schwann cells at the peak and recovery phases of EAN. Moreover, the putative netrin-1 receptor, deleted in colorectal cancer (DCC), was expressed mainly in axons, some macrophages, and Schwann cells in EAN-affected sciatic nerves, although the level of protein expression did not change significantly over the course of EAN. We suggest that a significant increase in netrin-1 expression contributes to host cell survival and axon regeneration to counter autoimmune injury and inflammation, which may play a role in recovery from EAN-induced paralysis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD11b,
http://linkedlifedata.com/resource/pubmed/chemical/Dcc protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin P2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphopyruvate Hydratase,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/S100 Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/myelin P2 protein (53-78),
http://linkedlifedata.com/resource/pubmed/chemical/netrin-1
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
172
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
66-72
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16337279-Animals,
pubmed-meshheading:16337279-Antigens, CD11b,
pubmed-meshheading:16337279-Blotting, Western,
pubmed-meshheading:16337279-Cell Death,
pubmed-meshheading:16337279-Disease Models, Animal,
pubmed-meshheading:16337279-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:16337279-Female,
pubmed-meshheading:16337279-Gene Expression Regulation,
pubmed-meshheading:16337279-Immunohistochemistry,
pubmed-meshheading:16337279-In Situ Nick-End Labeling,
pubmed-meshheading:16337279-Myelin P2 Protein,
pubmed-meshheading:16337279-Nerve Growth Factors,
pubmed-meshheading:16337279-Peptide Fragments,
pubmed-meshheading:16337279-Phosphopyruvate Hydratase,
pubmed-meshheading:16337279-Protein Binding,
pubmed-meshheading:16337279-Rats,
pubmed-meshheading:16337279-Rats, Inbred Lew,
pubmed-meshheading:16337279-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:16337279-Receptors, Cell Surface,
pubmed-meshheading:16337279-S100 Proteins,
pubmed-meshheading:16337279-Sciatic Nerve,
pubmed-meshheading:16337279-Signal Transduction,
pubmed-meshheading:16337279-Time Factors,
pubmed-meshheading:16337279-Tumor Suppressor Proteins
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pubmed:year |
2006
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pubmed:articleTitle |
Enhanced expression of netrin-1 protein in the sciatic nerves of Lewis rats with experimental autoimmune neuritis: possible role of the netrin-1/DCC binding pathway in an autoimmune PNS disorder.
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pubmed:affiliation |
Department of Veterinary Medicine, Cheju National University, Ara-1-dong, Jeju 690-756, South Korea.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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