Linked Life Data

16336968

Source:http://linkedlifedata.com/resource/pubmed/id/16336968

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-2-20
pubmed:abstractText
Peripheral nerve injury is a significant clinical problem that is often difficult to treat. The major clinical symptoms are numbness, tactile and cooling allodynia, hyperalgesias as well as ongoing pain. In animal models of neuropathy, abnormal responses to applied (or evoked) stimuli can be gauged, but spontaneous pain, a major clinical issue, has proved very difficult to assess. In neuropathic animals, spinal neuronal hyperexcitability indicative of peripheral and central changes with high levels of spontaneous neuronal firing has been reported. This latter stimulus-independent firing of sensory neurones may be a measure related to ongoing pain. Two weeks after L5/6 spinal nerve ligation, deep dorsal horn neurones were recorded in halothane-anesthetized rats. The majority of neurones in neuropathic rats showed increased levels of spontaneous firing with irregular firing patterns. We examined and compared the effects of 5 centrally acting pharmacological agents: morphine (i.t. or i.v.), gabapentin, ketamine, memantine and mepyramine on stimulus-independent neuronal firing. This ongoing activity showed high sensitivity to gabapentin (s.c.) and morphine (i.t.) administration, being significantly reduced in a dose-dependent manner. Morphine administered via the systemic route produced modest but non-significant reductions of spontaneous activity. The two NMDA receptor antagonists, ketamine and memantine, and the histamine H1 receptor antagonist, mepyramine, produced minor effects at doses known to be effective on stimulus evoked measures of deep dorsal horn neurones. This may form an electrophysiological basis for the efficacy of gabapentin and spinal morphine on ongoing pain in patients with peripheral neuropathy.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0014-4886
pubmed:author
pubmed:issnType
Print
pubmed:volume
198
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
72-80
pubmed:dateRevised
2007-8-13
pubmed:meshHeading
pubmed-meshheading:16336968-Action Potentials, pubmed-meshheading:16336968-Amines, pubmed-meshheading:16336968-Analgesics, pubmed-meshheading:16336968-Animals, pubmed-meshheading:16336968-Anticonvulsants, pubmed-meshheading:16336968-Behavior, Animal, pubmed-meshheading:16336968-Cyclohexanecarboxylic Acids, pubmed-meshheading:16336968-Disease Models, Animal, pubmed-meshheading:16336968-Dose-Response Relationship, Drug, pubmed-meshheading:16336968-Functional Laterality, pubmed-meshheading:16336968-Male, pubmed-meshheading:16336968-Morphine, pubmed-meshheading:16336968-Neurons, pubmed-meshheading:16336968-Pain Measurement, pubmed-meshheading:16336968-Peripheral Nervous System Diseases, pubmed-meshheading:16336968-Rats, pubmed-meshheading:16336968-Rats, Sprague-Dawley, pubmed-meshheading:16336968-Spinal Cord, pubmed-meshheading:16336968-Time Factors, pubmed-meshheading:16336968-gamma-Aminobutyric Acid
pubmed:year
2006
pubmed:articleTitle
Differential pharmacological modulation of the spontaneous stimulus-independent activity in the rat spinal cord following peripheral nerve injury.
pubmed:affiliation
Department of Pharmacology, Medical Sciences Building, University College London, Gower Street, London WC1E 6BT, UK. ucklrsu@ucl.ac.uk
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't