Linked Life Data

16335696

Source:http://linkedlifedata.com/resource/pubmed/id/16335696

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2005-12-12
pubmed:abstractText
Type 2 DM represents a multifactorial disease--both genetic and environmental factors are implicated in the etiology. In spite of an enormous effort, unraveling the genetics of type 2 DM has proved problematic. A polygenic inheritance is proposed for most cases. More than 250 candidate genes have been studied and increasing attention is being directed at two of them: the PPARgamma2 gene (peroxisome proliferator-activated receptor gama2) and KCNJ11 (potassium channel inwardly rectifying). The PPARgamma2 is a member of the nuclear hormone receptor subfamily of transcription factors. It plays a key role in regulation of adipocyte differentiation and energy balance. The KCNJ11 gene codes for a pore-forming subunit of the inwardly rectifying ATP sensitive K+ channel, which is involved in the direct regulation of insulin secretion. Here, recent knowledge regarding involvement of these two genes in complex metabolic pathways is summarized. In the whole review, we focus on the glucose homeostasis.
pubmed:language
cze
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0008-7335
pubmed:author
pubmed:issnType
Print
pubmed:volume
144
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
721-5; discussion 725-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
[Two promising candidate genes in the ethiopathogenesis of DM2 - PPARgamma2 and KCNJ11].
pubmed:affiliation
Endokrinologický ustav, Praha. dvejrazkova@endo.cz
pubmed:publicationType
Journal Article, English Abstract, Review