Linked Life Data

16333099

Source:http://linkedlifedata.com/resource/pubmed/id/16333099

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2005-12-7
pubmed:abstractText
Invasive pneumococcal disease is a significant cause of morbidity and mortality worldwide. The aim of this study was to establish the serotypes responsible for pneumococcal disease and the serotypes responsible for penicillin resistance in Noumea, New Caledonia. Isolates of Streptococcus pneumoniae from all body sites referred to the Microbiology Department of the Pasteur Institute in New Caledonia between May 1999 and May 2001 had serotyping and susceptibility testing performed. Basic demographic data on patients were also collected. A total of 298 isolates were included in the study. The most common serotypes were types 1 (20%), 23F (10%), 12F (8%), 19F (8%), and 6B (5%). The serotype distribution differed significantly with age, site of collection, and ethnicity. Overall, 280 of 298 (94%) of the isolates had serogroups that are included in the 23-valent vaccine. However, only 14 of 20 (70%) of the isolates associated with invasive disease from children younger than 5 years of age and 26 of 113 (23%) of invasive isolates from patients more than 5 years of age were included in the new 7-valent conjugate vaccine. Overall, reduced susceptibility to penicillin was found in 43 of 298 (14.4%) of the isolates, with 13% falling into the intermediate resistance category and only 5 (2%) being high-level resistant. A higher prevalence of penicillin resistance occurred in younger age groups and in European patients and involved specifically certain serotypes. The 7-valent conjugate pneumococcal vaccine has potential benefit for the New Caledonian population under 5 years of age and should be considered for future vaccines schedules.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16333099-11062803, http://linkedlifedata.com/resource/pubmed/commentcorrection/16333099-11062805, http://linkedlifedata.com/resource/pubmed/commentcorrection/16333099-11740313, http://linkedlifedata.com/resource/pubmed/commentcorrection/16333099-11954752, http://linkedlifedata.com/resource/pubmed/commentcorrection/16333099-12442021, http://linkedlifedata.com/resource/pubmed/commentcorrection/16333099-12724479, http://linkedlifedata.com/resource/pubmed/commentcorrection/16333099-14605125, http://linkedlifedata.com/resource/pubmed/commentcorrection/16333099-1536052, http://linkedlifedata.com/resource/pubmed/commentcorrection/16333099-2913022, http://linkedlifedata.com/resource/pubmed/commentcorrection/16333099-8824973, http://linkedlifedata.com/resource/pubmed/commentcorrection/16333099-8843213, http://linkedlifedata.com/resource/pubmed/commentcorrection/16333099-9534975, http://linkedlifedata.com/resource/pubmed/commentcorrection/16333099-9636862
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0095-1137
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6060-3
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Distribution of Streptococcus pneumoniae serotypes responsible for penicillin resistance and the potential role of new conjugate vaccines in New Caledonia.
pubmed:affiliation
Institut Pasteur of New Caledonia, BP 220, Dakar, Sénégal.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't