Linked Life Data

16333030

Source:http://linkedlifedata.com/resource/pubmed/id/16333030

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
2005-12-7
pubmed:abstractText
We previously developed an estrogen receptor (ER)-positive breast cancer cell line (MCF-7:5C) that is resistant to long-term estrogen deprivation and undergoes rapid and complete apoptosis in the presence of physiologic concentrations of 17beta-estradiol. Here, we investigated the role of the mitochondrial apoptotic pathway in this process.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Annexin A5, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95, http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Hormonal, http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins, http://linkedlifedata.com/resource/pubmed/chemical/BBC3 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/CASP8 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Caspase 8, http://linkedlifedata.com/resource/pubmed/chemical/Caspases, http://linkedlifedata.com/resource/pubmed/chemical/Cytochromes c, http://linkedlifedata.com/resource/pubmed/chemical/Estradiol, http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/FASLG protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Fas Ligand Protein, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/PARP1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/PMAIP1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Poly(ADP-ribose) Polymerases, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factors, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53, http://linkedlifedata.com/resource/pubmed/chemical/fulvestrant
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1460-2105
pubmed:author
pubmed:issnType
Electronic
pubmed:day
7
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1746-59
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:16333030-Annexin A5, pubmed-meshheading:16333030-Antigens, CD95, pubmed-meshheading:16333030-Antineoplastic Agents, Hormonal, pubmed-meshheading:16333030-Apoptosis, pubmed-meshheading:16333030-Apoptosis Regulatory Proteins, pubmed-meshheading:16333030-Blotting, Western, pubmed-meshheading:16333030-Breast Neoplasms, pubmed-meshheading:16333030-Caspase 8, pubmed-meshheading:16333030-Caspases, pubmed-meshheading:16333030-Cell Line, Tumor, pubmed-meshheading:16333030-Cell Proliferation, pubmed-meshheading:16333030-Cytochromes c, pubmed-meshheading:16333030-Estradiol, pubmed-meshheading:16333030-Estrogen Antagonists, pubmed-meshheading:16333030-Fas Ligand Protein, pubmed-meshheading:16333030-Female, pubmed-meshheading:16333030-Flow Cytometry, pubmed-meshheading:16333030-Gene Expression Regulation, Neoplastic, pubmed-meshheading:16333030-Humans, pubmed-meshheading:16333030-In Situ Nick-End Labeling, pubmed-meshheading:16333030-Membrane Glycoproteins, pubmed-meshheading:16333030-Microscopy, Electron, pubmed-meshheading:16333030-Mitochondria, pubmed-meshheading:16333030-Poly(ADP-ribose) Polymerases, pubmed-meshheading:16333030-Polymerase Chain Reaction, pubmed-meshheading:16333030-Proto-Oncogene Proteins, pubmed-meshheading:16333030-Proto-Oncogene Proteins c-bcl-2, pubmed-meshheading:16333030-RNA, Small Interfering, pubmed-meshheading:16333030-Signal Transduction, pubmed-meshheading:16333030-Transfection, pubmed-meshheading:16333030-Tumor Necrosis Factors, pubmed-meshheading:16333030-Tumor Suppressor Protein p53, pubmed-meshheading:16333030-Up-Regulation
pubmed:year
2005
pubmed:articleTitle
Intrinsic mechanism of estradiol-induced apoptosis in breast cancer cells resistant to estrogen deprivation.
pubmed:affiliation
Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural