|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0023434,
umls-concept:C0038952,
umls-concept:C0085732,
umls-concept:C0185117,
umls-concept:C0232901,
umls-concept:C0332281,
umls-concept:C1421567,
umls-concept:C1527940,
umls-concept:C1553423,
umls-concept:C1705831,
umls-concept:C1710082,
umls-concept:C2349975,
umls-concept:C2911684
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2006-4-21
|
|
pubmed:abstractText |
Molecular markers like IgV(H) mutational status, chromosomal abnormalities, and CD38 and ZAP-70 expression have prognostic value in B-cell chronic lymphocytic leukemia (B-CLL). These may be pathogenetic because of the coincidental expression of ZAP-70 and increased B-cell receptor (BCR) signaling and the signaling function of CD38 in CLL. This study shows that ZAP-70(+) CLL B cells respond in vitro more readily than ZAP-70(-) CLL and normal B cells to chemokine migratory signals through enhanced surface CCR7 expression (P = .009; P < .001) and increased responsiveness to its ligands CCL19 and CCL21, demonstrated by F-actin polymerization (P < .05) and cellular migration (P < .01). In addition, ZAP-70(+) CLL cells exhibit sustained ERK phosphorylation/activation following stimulation with CXCL12 (SDF1-alpha, a survival factor produced by stromal cells) compared with ZAP-70(-) cells (P = .004). Following coculture with nurse-like cells, the survival of ZAP-70(+) but not ZAP-70(-) CLL cells is significantly enhanced by the addition of CXCL12 (P < .05), an effect that is partially blocked by the MEK inhibitor PD98059. These advantageous migratory and survival responses may promote easier access to and greater proliferation in pseudo-germinal centers and explain in part the more progressive nature of ZAP-70(+) disease.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCL19 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CCL21 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CCR7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CXCL12 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL19,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL21,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL12,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CC,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR7,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR4,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine,
http://linkedlifedata.com/resource/pubmed/chemical/ZAP-70 Protein-Tyrosine Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/ZAP70 protein, human
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0006-4971
|
|
pubmed:author |
pubmed-author:AlexanderH DenisHD,
pubmed-author:CareyB SeanBS,
pubmed-author:CatherwoodMark AMA,
pubmed-author:CopplestoneJ AdrianJA,
pubmed-author:FarrugiaJoannaJ,
pubmed-author:GardinerAnneA,
pubmed-author:MatthewsChristineC,
pubmed-author:MouldSarahS,
pubmed-author:OscierDavidD,
pubmed-author:PrenticeArchibald GAG,
pubmed-author:RichardsonSarah JSJ
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
107
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3584-92
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:16332969-Case-Control Studies,
pubmed-meshheading:16332969-Cell Movement,
pubmed-meshheading:16332969-Cell Survival,
pubmed-meshheading:16332969-Chemokine CCL19,
pubmed-meshheading:16332969-Chemokine CCL21,
pubmed-meshheading:16332969-Chemokine CXCL12,
pubmed-meshheading:16332969-Chemokines, CC,
pubmed-meshheading:16332969-Chemokines, CXC,
pubmed-meshheading:16332969-Genes, Immunoglobulin,
pubmed-meshheading:16332969-Humans,
pubmed-meshheading:16332969-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:16332969-MAP Kinase Signaling System,
pubmed-meshheading:16332969-Models, Biological,
pubmed-meshheading:16332969-Mutation,
pubmed-meshheading:16332969-Receptors, CCR7,
pubmed-meshheading:16332969-Receptors, CXCR4,
pubmed-meshheading:16332969-Receptors, Chemokine,
pubmed-meshheading:16332969-Signal Transduction,
pubmed-meshheading:16332969-ZAP-70 Protein-Tyrosine Kinase
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL).
|
|
pubmed:affiliation |
Department of Haematology Level 7, Derriford Hospital, Plymouth PL6 8DH, United Kingdom. sarah.richardson@phnt.swest.nhs.uk
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
