Linked Life Data

16332719

Source:http://linkedlifedata.com/resource/pubmed/id/16332719

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2005-12-26
pubmed:abstractText
We report a rare case in which two tumor entities, a gastrointestinal stromal tumor (GIST) and Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET), with distinct cytogenetic features occurred in a single patient. The patient was a 72-year-old woman. The first tumor was a submucosal gastric tumor and was diagnosed as a low-risk group GIST based on morphological characteristics and the results of an immunohistochemical analysis for c-kit and CD34. Further cytogenetic analysis revealed that this tumor had a point mutation (D842V substitution) in exon 18 of the platelet-derived growth factor receptor alpha gene. The second tumor was found more than 4 years after the appearance of the first tumor. ES/PNET was highly suspected both morphologically and immunohistochemically, and the diagnosis was confirmed by the detection of an EWS rearrangement using a fluorescence in situ hybridization technique. Although the cytogenetic correlations of these two tumors are unclear, accurate histologic recognition is of clinical importance because the treatments for these two tumors differ.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0368-2811
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
753-6
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:16332719-Aged, pubmed-meshheading:16332719-Antigens, CD34, pubmed-meshheading:16332719-Cytogenetic Analysis, pubmed-meshheading:16332719-Female, pubmed-meshheading:16332719-Gastrointestinal Stromal Tumors, pubmed-meshheading:16332719-Humans, pubmed-meshheading:16332719-In Situ Hybridization, Fluorescence, pubmed-meshheading:16332719-Neoplasms, Multiple Primary, pubmed-meshheading:16332719-Neuroectodermal Tumors, Primitive, pubmed-meshheading:16332719-Point Mutation, pubmed-meshheading:16332719-Polymerase Chain Reaction, pubmed-meshheading:16332719-Proto-Oncogene Proteins c-kit, pubmed-meshheading:16332719-RNA-Binding Protein EWS, pubmed-meshheading:16332719-Receptor, Platelet-Derived Growth Factor alpha, pubmed-meshheading:16332719-Retroperitoneal Neoplasms, pubmed-meshheading:16332719-Sarcoma, Ewing, pubmed-meshheading:16332719-Stomach Neoplasms
pubmed:year
2005
pubmed:articleTitle
Cytogenetic confirmation of a gastrointestinal stromal tumor and ewing sarcoma/primitive neuroectodermal tumor in a single patient.
pubmed:affiliation
Divison of Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.
pubmed:publicationType
Journal Article, Case Reports, Research Support, Non-U.S. Gov't