16332437

Source:http://linkedlifedata.com/resource/pubmed/id/16332437

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0205531, umls-concept:C0226896, umls-concept:C0442027, umls-concept:C0935763, umls-concept:C1527415, umls-concept:C1880355, umls-concept:C2917254
pubmed:issue	5
pubmed:dateCreated	2006-1-27
pubmed:abstractText	anti-Substituted beta-methylphenylalanine derived amides have been shown to be potent DPP-IV inhibitors exhibiting excellent selectivity over both DPP8 and DPP9. The optimized compound exhibited good pharmacokinetic profiles in three preclinical species.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Deaminase, http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Deaminase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Amides, http://linkedlifedata.com/resource/pubmed/chemical/DPP4 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Dipeptidyl Peptidase 4, http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Nitrogen, http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Pyridones
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	0960-894X
pubmed:author	pubmed-author:EdmondsonScott DSD, pubmed-author:EiermannGeorge JGJ, pubmed-author:HeHuaibingH, pubmed-author:LeitingBarbaraB, pubmed-author:LeoneJoseph FJF, pubmed-author:LyonsKathryn AKA, pubmed-author:MarsilioFrankF, pubmed-author:MastracchioAnthonyA, pubmed-author:MathvinkRobertR, pubmed-author:PatelReshma ARA, pubmed-author:PetrovAleksandrA, pubmed-author:ThornberryNancy ANA, pubmed-author:WeberAnn EAE, pubmed-author:WeiLanL, pubmed-author:WuJoseph KJK, pubmed-author:XuJinyouJ
pubmed:issnType	Print
pubmed:day	1
pubmed:volume	16
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1346-9
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:16332437-Adenosine Deaminase, pubmed-meshheading:16332437-Adenosine Deaminase Inhibitors, pubmed-meshheading:16332437-Administration, Oral, pubmed-meshheading:16332437-Amides, pubmed-meshheading:16332437-Animals, pubmed-meshheading:16332437-Biological Availability, pubmed-meshheading:16332437-Dipeptidyl Peptidase 4, pubmed-meshheading:16332437-Dogs, pubmed-meshheading:16332437-Glycoproteins, pubmed-meshheading:16332437-Humans, pubmed-meshheading:16332437-Inhibitory Concentration 50, pubmed-meshheading:16332437-Macaca mulatta, pubmed-meshheading:16332437-Molecular Structure, pubmed-meshheading:16332437-Nitrogen, pubmed-meshheading:16332437-Protease Inhibitors, pubmed-meshheading:16332437-Pyridones, pubmed-meshheading:16332437-Rats, pubmed-meshheading:16332437-Sensitivity and Specificity, pubmed-meshheading:16332437-Structure-Activity Relationship, pubmed-meshheading:16332437-Substrate Specificity
pubmed:year	2006
pubmed:articleTitle	Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors.
pubmed:affiliation	Department of Medicinal Chemistry, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA. Jinyou_Xu@merck.com
pubmed:publicationType	Journal Article