Source:http://linkedlifedata.com/resource/pubmed/id/16331753
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
2005-12-6
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pubmed:abstractText |
We describe a unique family where each of the 5 siblings in the second generation has rheumatoid arthritis (RA). Two other members of the family have RA and systemic lupus erythematosus (SLE), respectively. No members of previous generations in the family had documented inflammatory arthritis. Due to the suspected genetic predisposition, HLA-DR genotypes were determined in the affected siblings and their parents, children, and grandchildren. We investigated the possible role of various HLA-DR alleles in the evolution of RA in this multicase family.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0315-162X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2299-302
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16331753-Adult,
pubmed-meshheading:16331753-Arthritis, Rheumatoid,
pubmed-meshheading:16331753-Female,
pubmed-meshheading:16331753-Gene Frequency,
pubmed-meshheading:16331753-Genetic Predisposition to Disease,
pubmed-meshheading:16331753-Genotype,
pubmed-meshheading:16331753-HLA-DR Antigens,
pubmed-meshheading:16331753-HLA-DRB1 Chains,
pubmed-meshheading:16331753-Humans,
pubmed-meshheading:16331753-Lupus Erythematosus, Systemic,
pubmed-meshheading:16331753-Male,
pubmed-meshheading:16331753-Middle Aged,
pubmed-meshheading:16331753-Pedigree
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pubmed:year |
2005
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pubmed:articleTitle |
HLA-DR genotypes in familial rheumatoid arthritis: increased frequency of protective and neutral alleles in a multicase family.
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pubmed:affiliation |
National Institute of Rheumatology and Physiotherapy, Budapest, Hungary. zsilaksz@freemail.hu
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pubmed:publicationType |
Journal Article
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