Linked Life Data

16331394

Source:http://linkedlifedata.com/resource/pubmed/id/16331394

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-12-6
pubmed:abstractText
REM sleep behaviour disorder (RBD) is a parasomnia characterised by nocturnal complex motor activity associated with dream mentation. RBD, which affects mainly older men, may be idiopathic or associated with other neurological disorders. A strong association between RBD and alpha-synucleinopathies has been recently observed, with the parasomnia often heralding the clinical onset of the neurodegenerative disease. The idiopathic form accounts for up to 60% of the cases reported in the three largest series of RBD patients. Follow-up studies in small samples revealed that a proportion of RBD patients will eventually develop Parkinson's disease and/or a dementia of Lewy bodies type in the years following the RBD diagnosis. Recently, neurophysiological and neuropsychological studies in idiopathic RBD have found evidence of central nervous system dysfunction. An impairment of cortical activity, specific neuropsychological deficits, signs of autonomic dysfunction and olfactory impairment have been observed in these patients, challenging the concept of idiopathic RBD. The detection of early markers of neurodegenerative disorders in idiopathic RBD, and the evaluation of their value by the combined application in prospective studies may be crucial for developing early intervention strategies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1590-1874
pubmed:author
pubmed:issnType
Print
pubmed:volume
26 Suppl 3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
s186-92
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
REM sleep behaviour disorder.
pubmed:affiliation
Sleep Disorders Center, Department of Neurology, Università Vita-Salute San Raffaele, Via Stamira d'Ancona 20, I-20127 Milan, Italy. ferinistrambi.luigi@hsr.it
pubmed:publicationType
Journal Article, Review, Controlled Clinical Trial