Source:http://linkedlifedata.com/resource/pubmed/id/16330501
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
Pt 2
|
| pubmed:dateCreated |
2006-1-25
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| pubmed:abstractText |
Selective verb and noun deficits have been observed in a number of neurological conditions and their occurrence has been interpreted as evidence for different neural networks underlying the processing of specific word categories. We describe the first case of a familial occurrence of a selective deficit of verb processing. Father (Individual I) and son (Individual II) developed a movement disorder resembling progressive supranuclear palsy (PSP) and associated with dementia. A second child of Individual II remained symptom-free on consecutive examinations. The dissociation between the processing of nouns and verbs in Individuals I and II was confirmed with different methods, including a longitudinal assessment of naming, comprehension, picture and word association, as well as a lexical decision task. The difference remained stable on follow-up testing despite overall deterioration. It was associated with left-sided frontal hypometabolism on FDG-PET imaging (Individual II) and with ubiquitin-positive inclusions on post-mortem examination (Individual I). The association of a selective verb deficit with a familial movement disorder raises the question whether related genetic factors might influence both movements and their abstract conceptual representations in the form of action verbs. By demonstrating a link between pathology, genetics, imaging and abstract cognitive impairments this study advances our understanding of degenerative brain disease with implications for both neuroscience and clinical practice.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1460-2156
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
129
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
321-32
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16330501-Adult,
pubmed-meshheading:16330501-Aged,
pubmed-meshheading:16330501-Dementia,
pubmed-meshheading:16330501-Female,
pubmed-meshheading:16330501-Frontal Lobe,
pubmed-meshheading:16330501-Heterozygote,
pubmed-meshheading:16330501-Humans,
pubmed-meshheading:16330501-Immunohistochemistry,
pubmed-meshheading:16330501-Inclusion Bodies,
pubmed-meshheading:16330501-Male,
pubmed-meshheading:16330501-Motion Perception,
pubmed-meshheading:16330501-Neurites,
pubmed-meshheading:16330501-Neurons,
pubmed-meshheading:16330501-Neuropsychological Tests,
pubmed-meshheading:16330501-Pedigree,
pubmed-meshheading:16330501-Positron-Emission Tomography,
pubmed-meshheading:16330501-Supranuclear Palsy, Progressive,
pubmed-meshheading:16330501-Ubiquitin,
pubmed-meshheading:16330501-Verbal Behavior,
pubmed-meshheading:16330501-tau Proteins
|
| pubmed:year |
2006
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| pubmed:articleTitle |
Clinical, imaging and pathological correlates of a hereditary deficit in verb and action processing.
|
| pubmed:affiliation |
MRC Cognition and Brain Sciences Unit, Addenbrooke's Hospital, UK.
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| pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|