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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2005-12-6
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pubmed:abstractText |
We recently reported that hypoxia-mimetic agents cobalt chloride (CoCl2 CoCl2 ) and desferrioxamine (DFO) could induce differentiation of acute myeloid leukemic (AML) cells. Here, we investigate whether these two agents influence the in vitro differentiation-inducing effect of arsenic trioxide (As2O3) on AML cells, an effective drug for the treatment of acute promyelocytic leukemia (APL) that is a unique subtype of AML with a specific fusion protein, PML-RARalpha.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Arsenicals,
http://linkedlifedata.com/resource/pubmed/chemical/Cobalt,
http://linkedlifedata.com/resource/pubmed/chemical/Deferoxamine,
http://linkedlifedata.com/resource/pubmed/chemical/HIF1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion,
http://linkedlifedata.com/resource/pubmed/chemical/Oxides,
http://linkedlifedata.com/resource/pubmed/chemical/Oxygen,
http://linkedlifedata.com/resource/pubmed/chemical/Tretinoin,
http://linkedlifedata.com/resource/pubmed/chemical/arsenic trioxide,
http://linkedlifedata.com/resource/pubmed/chemical/cobaltous chloride,
http://linkedlifedata.com/resource/pubmed/chemical/promyelocytic leukemia-retinoic...
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1592-8721
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1607-16
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16330433-Antineoplastic Agents,
pubmed-meshheading:16330433-Arsenicals,
pubmed-meshheading:16330433-Bone Marrow,
pubmed-meshheading:16330433-Cell Differentiation,
pubmed-meshheading:16330433-Cell Division,
pubmed-meshheading:16330433-Cell Hypoxia,
pubmed-meshheading:16330433-Cell Line, Tumor,
pubmed-meshheading:16330433-Cobalt,
pubmed-meshheading:16330433-Deferoxamine,
pubmed-meshheading:16330433-Drug Synergism,
pubmed-meshheading:16330433-Gene Expression Regulation, Leukemic,
pubmed-meshheading:16330433-Humans,
pubmed-meshheading:16330433-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:16330433-Leukemia, Promyelocytic, Acute,
pubmed-meshheading:16330433-Neoplasm Proteins,
pubmed-meshheading:16330433-Oncogene Proteins, Fusion,
pubmed-meshheading:16330433-Oxides,
pubmed-meshheading:16330433-Oxygen,
pubmed-meshheading:16330433-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16330433-Tretinoin,
pubmed-meshheading:16330433-U937 Cells
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pubmed:year |
2005
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pubmed:articleTitle |
Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells.
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pubmed:affiliation |
Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Rui-Jin Hospital, Shanghai Jiao-Tong University (SJU-SM, formerly named Shanghai Second Medical University), Shanghai 200025, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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