Source:http://linkedlifedata.com/resource/pubmed/id/16330179
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2006-5-30
|
| pubmed:abstractText |
Chronic psychological stress has been suggested to play a role in disorders in which the immune system unexpectedly fails to respond in a protective manner. Chronic combined acoustic and restraint stress compromises the anti-bacterial defense mechanisms of female BALB/c mice. The immunodeficiency is characterized by an apoptotic loss of lymphocytes, reduced ex vivo-inducibility of TNF but increased inducibility of IL10, reduced T-cell proliferation, and impaired phagocyte functions. Stressed mice develop depression-like behavior that was monitored by a stress severity score (SSS). Besides a strain (BALB/c>CBA) and gender (male>female) dependent susceptibility to chronic stress, inbred mice have an individual coping ability. Importantly, the individual SSS strongly correlates with Escherichia coli dissemination after infection as well as with IL10-inducibility and circulating corticosterone levels of each animal.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0889-1591
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
359-68
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:16330179-Acoustic Stimulation,
pubmed-meshheading:16330179-Adaptation, Physiological,
pubmed-meshheading:16330179-Animals,
pubmed-meshheading:16330179-Bacterial Infections,
pubmed-meshheading:16330179-Chronic Disease,
pubmed-meshheading:16330179-Cytokines,
pubmed-meshheading:16330179-Depression,
pubmed-meshheading:16330179-Disease Models, Animal,
pubmed-meshheading:16330179-Female,
pubmed-meshheading:16330179-Lymphocyte Count,
pubmed-meshheading:16330179-Lymphocyte Subsets,
pubmed-meshheading:16330179-Male,
pubmed-meshheading:16330179-Mice,
pubmed-meshheading:16330179-Mice, Inbred BALB C,
pubmed-meshheading:16330179-Mice, Inbred CBA,
pubmed-meshheading:16330179-Neuroimmunomodulation,
pubmed-meshheading:16330179-Random Allocation,
pubmed-meshheading:16330179-Restraint, Physical,
pubmed-meshheading:16330179-Severity of Illness Index,
pubmed-meshheading:16330179-Sex Factors,
pubmed-meshheading:16330179-Species Specificity,
pubmed-meshheading:16330179-Statistics, Nonparametric,
pubmed-meshheading:16330179-Stress, Psychological
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Stress susceptibility predicts the severity of immune depression and the failure to combat bacterial infections in chronically stressed mice.
|
| pubmed:affiliation |
Department of Immunology, University of Greifswald, Germany.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|