Source:http://linkedlifedata.com/resource/pubmed/id/16328347
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
2006-4-4
|
pubmed:abstractText |
Claudins are involved in the formation of tight junctions in epithelial and endothelial cells. Claudins form a family of 24 members displaying organ- and tissue-specific patterns of expression. In the present study, we evaluated the specificity of the claudin-2 expression in various normal human tissues and gastrointestinal cancers by quantitative reverse transcriptase-polymerase chain reaction and immunohistochemistry. In 14 various normal tissues, claudin-2 mRNA was expressed in the kidney, liver, pancreas, stomach, and small intestine; the highest level of which was detected in the kidney. Colorectal cancers (CRCs) expressed claudin-2 mRNA at high levels. Immunohistochemical analysis of claudin-2 in 146 gastric cancers (GCs) and 99 CRCs demonstrated claudin-2 expression in 2.1% of GCs and 25.3% of CRCs, respectively. There was no obvious correlation between claudin-2 expression and clinicopathological parameters of CRCs. These results suggest that the expression of claudin-2 may involve organ specificity, and increased expression of claudin-2 may participate in colorectal carcinogenesis.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0945-6317
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
448
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
428-34
|
pubmed:meshHeading |
pubmed-meshheading:16328347-Adenocarcinoma,
pubmed-meshheading:16328347-Cell Line, Tumor,
pubmed-meshheading:16328347-Colorectal Neoplasms,
pubmed-meshheading:16328347-Gene Expression,
pubmed-meshheading:16328347-Gene Expression Profiling,
pubmed-meshheading:16328347-Humans,
pubmed-meshheading:16328347-Immunoenzyme Techniques,
pubmed-meshheading:16328347-Membrane Proteins,
pubmed-meshheading:16328347-Neoplasm Staging,
pubmed-meshheading:16328347-RNA, Messenger,
pubmed-meshheading:16328347-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16328347-Stomach Neoplasms,
pubmed-meshheading:16328347-Tumor Markers, Biological
|
pubmed:year |
2006
|
pubmed:articleTitle |
Differential expression of claudin-2 in normal human tissues and gastrointestinal carcinomas.
|
pubmed:affiliation |
Department of Molecular Pathology, Graduate School of Biomedical Sciences Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|