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rdf:type |
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lifeskim:mentions |
umls-concept:C0025938,
umls-concept:C0031740,
umls-concept:C0114214,
umls-concept:C0184511,
umls-concept:C0205169,
umls-concept:C0334227,
umls-concept:C0450442,
umls-concept:C0599733,
umls-concept:C1274040,
umls-concept:C1533691,
umls-concept:C1721164,
umls-concept:C1749467
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pubmed:issue |
3
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pubmed:dateCreated |
2006-3-13
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pubmed:abstractText |
Poorly soluble photodynamic therapy (PDT) agent, meso-tetratphenylporphine (TPP), was effectively solubilized using non-targeted and tumor-targeted polymeric micelles prepared of polyethylene glycol/phosphatidyl ethanolamine conjugate (PEG-PE). Encapsulation of TPP into PEG-PE-based micelles and immunomicelles (bearing an anti-cancer monoclonal 2C5 antibody) resulted in significantly improved anticancer effects of the drug at PDT conditions against murine (LLC, B16) and human (MCF-7, BT20) cancer cells in vitro. For this purpose, the cells were incubated for 6 or 18 h with the TPP or TPP-loaded PEG-PE micelles/immunomicelles and then light-irradiated for 30 min. The phototoxic effect depended on the TPP concentration and specific targeting by immunomicelles. An increased level of apoptosis was shown in the PDT-treated cultures. The attachment of the anti-cancer 2C5 antibodies to TPP-loaded micelles provided the maximum level of cell killing at a given time. The results of this study showed that TPP-containing PEG-PE micelles may represent a useful formulation of the photosensitizer for practical PDT.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-10459732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-10469928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-10610830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-10699287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-11094244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-11286983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-11438707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-11489487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-11516494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-12003128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-12716967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-1277137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-15109769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-15336264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-15451001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-1763060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-366635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-3703952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-7747800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-8537094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-9201165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-9349396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-9436197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-9637138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16326084-9727629
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0939-6411
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
235-40
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:16326084-Animals,
pubmed-meshheading:16326084-Antineoplastic Agents,
pubmed-meshheading:16326084-Apoptosis,
pubmed-meshheading:16326084-Cell Line, Tumor,
pubmed-meshheading:16326084-Cell Survival,
pubmed-meshheading:16326084-Drug Delivery Systems,
pubmed-meshheading:16326084-Drug Stability,
pubmed-meshheading:16326084-Excipients,
pubmed-meshheading:16326084-Humans,
pubmed-meshheading:16326084-Mice,
pubmed-meshheading:16326084-Micelles,
pubmed-meshheading:16326084-Particle Size,
pubmed-meshheading:16326084-Photochemotherapy,
pubmed-meshheading:16326084-Photosensitizing Agents,
pubmed-meshheading:16326084-Polyethylene Glycols,
pubmed-meshheading:16326084-Porphyrins
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pubmed:year |
2006
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pubmed:articleTitle |
Solubilization of poorly soluble PDT agent, meso-tetraphenylporphin, in plain or immunotargeted PEG-PE micelles results in dramatically improved cancer cell killing in vitro.
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pubmed:affiliation |
Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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