Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-1-12
pubmed:abstractText
Wnt signaling pathways have essential roles in developing embryos and adult tissue, and alterations in their function are implicated in many disease processes including cancers. The major nuclear transducers of Wnt signals are the Tcf/LEF family of transcription factors, which have binding sites for both the transcriptional co-repressor groucho, and the co-activator beta-catenin. The early Xenopus embryo expresses three maternally inherited Tcf/LEF mRNAs, and their relative roles in regulating the expression of Wnt target genes are not understood. We have addressed this by using antisense oligonucleotides to deplete maternal XTcf1 and XTcf4 mRNAs in oocytes. We find that XTcf1 represses expression of Wnt target genes ventrally and laterally, and activates their expression dorsally. Double depletions of XTcf1 and XTcf3 suggest that they act cooperatively to repress Wnt target genes ventrally. In contrast, XTcf4 has no repressive role but is required to activate expression of Xnr3 and chordin in organizer cells at the gastrula stage. This work provides evidence for distinct roles for XTcfs in regulating Wnt target gene expression.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Nuclear Factor 1-alpha, http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides..., http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/T Cell Transcription Factor 1, http://linkedlifedata.com/resource/pubmed/chemical/TCF Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor 7-Like 1..., http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor 7-Like 2..., http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta, http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Xenopus Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Xnr3 protein, Xenopus, http://linkedlifedata.com/resource/pubmed/chemical/chordin, http://linkedlifedata.com/resource/pubmed/chemical/hnf1a protein, Xenopus, http://linkedlifedata.com/resource/pubmed/chemical/tcf7l2 protein, Xenopus, http://linkedlifedata.com/resource/pubmed/chemical/wnt-11 protein, Xenopus
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0012-1606
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
289
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
318-28
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:16325796-Animals, pubmed-meshheading:16325796-Embryo, Nonmammalian, pubmed-meshheading:16325796-Gene Expression Regulation, Developmental, pubmed-meshheading:16325796-Glycoproteins, pubmed-meshheading:16325796-Hepatocyte Nuclear Factor 1-alpha, pubmed-meshheading:16325796-In Situ Hybridization, pubmed-meshheading:16325796-Intercellular Signaling Peptides and Proteins, pubmed-meshheading:16325796-RNA, Messenger, pubmed-meshheading:16325796-Repressor Proteins, pubmed-meshheading:16325796-T Cell Transcription Factor 1, pubmed-meshheading:16325796-TCF Transcription Factors, pubmed-meshheading:16325796-Transcription Factor 7-Like 1 Protein, pubmed-meshheading:16325796-Transcription Factor 7-Like 2 Protein, pubmed-meshheading:16325796-Transforming Growth Factor beta, pubmed-meshheading:16325796-Wnt Proteins, pubmed-meshheading:16325796-Xenopus, pubmed-meshheading:16325796-Xenopus Proteins
pubmed:year
2006
pubmed:articleTitle
Maternal XTcf1 and XTcf4 have distinct roles in regulating Wnt target genes.
pubmed:affiliation
Division of Developmental Biology ML7007, Cincinnati Children's Hospital Research Foundation, 3333 Burnet Avenue, OH 45229-3039, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural