| pubmed-article:16324833 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16324833 | lifeskim:mentions | umls-concept:C0231335 | lld:lifeskim |
| pubmed-article:16324833 | lifeskim:mentions | umls-concept:C0023449 | lld:lifeskim |
| pubmed-article:16324833 | lifeskim:mentions | umls-concept:C1824489 | lld:lifeskim |
| pubmed-article:16324833 | lifeskim:mentions | umls-concept:C0237881 | lld:lifeskim |
| pubmed-article:16324833 | lifeskim:mentions | umls-concept:C0220901 | lld:lifeskim |
| pubmed-article:16324833 | lifeskim:mentions | umls-concept:C0750502 | lld:lifeskim |
| pubmed-article:16324833 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16324833 | pubmed:dateCreated | 2006-1-30 | lld:pubmed |
| pubmed-article:16324833 | pubmed:abstractText | An important problem in the treatment of children with acute lymphoblastic leukaemia (ALL) is pre-existent or acquired resistance to structurally and functionally unrelated chemotherapeutic compounds. Various cellular mechanisms can give rise to multidrug resistance (MDR). Best studied is the transmembrane protein-mediated efflux of cytotoxic compounds that leads to decreased cellular drug accumulation and toxicity. Several MDR-related efflux pumps have been characterised, including P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1), breast cancer resistance protein (BCRP) and lung resistance protein (LRP). P-gp expression and/or activity has been associated with unfavourable outcome in paediatric ALL patients, whereas MRP1 and BCRP do not seem to play a major role. LRP might contribute to drug resistance in B-lineage ALL, but larger studies are needed to confirm these results. The present review summarises the current knowledge concerning multidrug resistance-related proteins and focuses on the clinical relevance and prognostic value of these efflux pumps in childhood ALL. | lld:pubmed |
| pubmed-article:16324833 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16324833 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16324833 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16324833 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16324833 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16324833 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16324833 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16324833 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16324833 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16324833 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16324833 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16324833 | pubmed:issn | 0959-8049 | lld:pubmed |
| pubmed-article:16324833 | pubmed:author | pubmed-author:BenoitYvesY | lld:pubmed |
| pubmed-article:16324833 | pubmed:author | pubmed-author:LaureysGenevi... | lld:pubmed |
| pubmed-article:16324833 | pubmed:author | pubmed-author:PhilippéJanJ | lld:pubmed |
| pubmed-article:16324833 | pubmed:author | pubmed-author:DhoogeCathari... | lld:pubmed |
| pubmed-article:16324833 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:16324833 | pubmed:author | pubmed-author:SwertsKatrien... | lld:pubmed |
| pubmed-article:16324833 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16324833 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:16324833 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16324833 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16324833 | pubmed:pagination | 295-309 | lld:pubmed |
| pubmed-article:16324833 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:16324833 | pubmed:meshHeading | pubmed-meshheading:16324833... | lld:pubmed |
| pubmed-article:16324833 | pubmed:meshHeading | pubmed-meshheading:16324833... | lld:pubmed |
| pubmed-article:16324833 | pubmed:meshHeading | pubmed-meshheading:16324833... | lld:pubmed |
| pubmed-article:16324833 | pubmed:meshHeading | pubmed-meshheading:16324833... | lld:pubmed |
| pubmed-article:16324833 | pubmed:meshHeading | pubmed-meshheading:16324833... | lld:pubmed |
| pubmed-article:16324833 | pubmed:meshHeading | pubmed-meshheading:16324833... | lld:pubmed |
| pubmed-article:16324833 | pubmed:meshHeading | pubmed-meshheading:16324833... | lld:pubmed |
| pubmed-article:16324833 | pubmed:meshHeading | pubmed-meshheading:16324833... | lld:pubmed |
| pubmed-article:16324833 | pubmed:meshHeading | pubmed-meshheading:16324833... | lld:pubmed |
| pubmed-article:16324833 | pubmed:meshHeading | pubmed-meshheading:16324833... | lld:pubmed |
| pubmed-article:16324833 | pubmed:meshHeading | pubmed-meshheading:16324833... | lld:pubmed |
| pubmed-article:16324833 | pubmed:meshHeading | pubmed-meshheading:16324833... | lld:pubmed |
| pubmed-article:16324833 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16324833 | pubmed:articleTitle | Prognostic significance of multidrug resistance-related proteins in childhood acute lymphoblastic leukaemia. | lld:pubmed |
| pubmed-article:16324833 | pubmed:affiliation | Department of Paediatric Haematology and Oncology, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium. katrien.swerts@ugent.be | lld:pubmed |
| pubmed-article:16324833 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16324833 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:16324833 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16324833 | lld:pubmed |
