rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
2006-1-30
|
pubmed:abstractText |
An important problem in the treatment of children with acute lymphoblastic leukaemia (ALL) is pre-existent or acquired resistance to structurally and functionally unrelated chemotherapeutic compounds. Various cellular mechanisms can give rise to multidrug resistance (MDR). Best studied is the transmembrane protein-mediated efflux of cytotoxic compounds that leads to decreased cellular drug accumulation and toxicity. Several MDR-related efflux pumps have been characterised, including P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1), breast cancer resistance protein (BCRP) and lung resistance protein (LRP). P-gp expression and/or activity has been associated with unfavourable outcome in paediatric ALL patients, whereas MRP1 and BCRP do not seem to play a major role. LRP might contribute to drug resistance in B-lineage ALL, but larger studies are needed to confirm these results. The present review summarises the current knowledge concerning multidrug resistance-related proteins and focuses on the clinical relevance and prognostic value of these efflux pumps in childhood ALL.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0959-8049
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
42
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
295-309
|
pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16324833-ATP-Binding Cassette Transporters,
pubmed-meshheading:16324833-Antineoplastic Agents,
pubmed-meshheading:16324833-Child,
pubmed-meshheading:16324833-Drug Resistance, Multiple,
pubmed-meshheading:16324833-Drug Resistance, Neoplasm,
pubmed-meshheading:16324833-Humans,
pubmed-meshheading:16324833-Multidrug Resistance-Associated Proteins,
pubmed-meshheading:16324833-Neoplasm Proteins,
pubmed-meshheading:16324833-P-Glycoprotein,
pubmed-meshheading:16324833-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:16324833-Prognosis,
pubmed-meshheading:16324833-Vault Ribonucleoprotein Particles
|
pubmed:year |
2006
|
pubmed:articleTitle |
Prognostic significance of multidrug resistance-related proteins in childhood acute lymphoblastic leukaemia.
|
pubmed:affiliation |
Department of Paediatric Haematology and Oncology, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium. katrien.swerts@ugent.be
|
pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|