Linked Life Data

16323415

Source:http://linkedlifedata.com/resource/pubmed/id/16323415

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-12-5
pubmed:abstractText
Dendritic cells (DC) are key players at the interface between innate resistance and cognate immunity. Recent evidence highlighted that innate effector cells can induce DC maturation, a checkpoint for the triggering of primary T cell responses in vivo. Moreover, mature DC also promote NK cell effector functions, necessary and sufficient, in some cases, for Th1 polarization. The site of the DC-NK cell interplay likely determines its relevance in physiopathology and the outcome on the ongoing immune response. This review focuses on the current knowledge of the regulation of NK cell priming by DC and, reciprocally, on the consequences of NK cell activation on DC functions. The relevance of DC-NK cell cross-talk in the control of infectious diseases and tumor growth is discussed, highlighting the impact of this dialogue on the design of immunotherapy protocols.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0070-217X
pubmed:author
pubmed:issnType
Print
pubmed:volume
298
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
157-74
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Dendritic cell-NK cell cross-talk: regulation and physiopathology.
pubmed:affiliation
Immunology Unit, ERM0208 INSERM, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France. zitvogel@igr.fr
pubmed:publicationType
Journal Article, Review