|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0018270,
umls-concept:C0023759,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0033414,
umls-concept:C0127400,
umls-concept:C0174680,
umls-concept:C0302600,
umls-concept:C0332466,
umls-concept:C1335205,
umls-concept:C1510411,
umls-concept:C1627358,
umls-concept:C2265597,
umls-concept:C2349975
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
2005-12-26
|
|
pubmed:abstractText |
Cleft lip with or without cleft palate is the most common congenital anomaly in the craniofacial region. Knowledge of the molecular mechanisms behind normal lip fusion can contribute to better intervention and improved functional clinical outcome. Transforming growth factor-beta3 (TGF-beta3) has been implicated in lip morphogenesis. Therefore, we hypothesized that TGF-beta3 functions during lip fusion through regulation of angiogenesis and mesenchymal cell cycle progression during early developmental stages.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
1542-0752
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
73
|
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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|
pubmed:pagination |
956-65
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|
pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16323168-Animals,
pubmed-meshheading:16323168-Antigens, CD31,
pubmed-meshheading:16323168-Cell Proliferation,
pubmed-meshheading:16323168-Cleft Lip,
pubmed-meshheading:16323168-Cyclin D1,
pubmed-meshheading:16323168-Disease Models, Animal,
pubmed-meshheading:16323168-Dose-Response Relationship, Drug,
pubmed-meshheading:16323168-Gene Expression Regulation, Developmental,
pubmed-meshheading:16323168-Mesoderm,
pubmed-meshheading:16323168-Mice,
pubmed-meshheading:16323168-Mice, Mutant Strains,
pubmed-meshheading:16323168-Neovascularization, Physiologic,
pubmed-meshheading:16323168-Organ Culture Techniques,
pubmed-meshheading:16323168-RNA, Messenger,
pubmed-meshheading:16323168-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16323168-Transforming Growth Factor beta,
pubmed-meshheading:16323168-Transforming Growth Factor beta3,
pubmed-meshheading:16323168-Vascular Endothelial Growth Factor Receptor-2
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|
pubmed:year |
2005
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|
pubmed:articleTitle |
Transforming growth factor-beta3 promotes mesenchymal cell proliferation and angiogenesis mediated by the enhancement of cyclin D1, Flk-1, and CD31 gene expression during CL/Fr mouse lip fusion.
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|
pubmed:affiliation |
Graduate School of Dental Science, Kyushu University, Fukuoka, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
