Source:http://linkedlifedata.com/resource/pubmed/id/16323006
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2006-4-4
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| pubmed:abstractText |
To better characterize ocular adnexal marginal zone lymphoma of mucosa-associated lymphoid tissue (MZL-MALT), we analyzed the clinical and pathologic features of 23 patients (11 men, 12 women, median age 66 years). The tumor was confined to one ocular structure in 18 cases (conjunctiva, n=8; orbit, n=8; or lacrimal gland, n=2). Concurrent extraorbital disease was detected by the staging procedure in five patients, and preferentially involved other MALT sites. Histogenetic B cell marker studies, available in 13 cases, showed an early post-germinal center (GC) phenotype (BCL-6(-)/IRF4(+)/CD138(-)) (n=5) or a late post-GC phenotype (BCL-6(-)/IRF4(+)/CD138(+)) (n=8), which could be helpful for discrimination from other types of small-B cell lymphoma. BCL10 was positive in 12 of 13 patients tested, with nuclear (n=4) or cytoplasmic (n=8) immunoreactivity. These staining patterns ruled out t(1;14)(p22;q32) translocation. T(11;18)(q21;q21), another MZL-MALT-specific translocation, was detected by reverse transcriptase polymerase chain reaction in four of 15 patients tested. Clinical outcome was excellent but the overall relapse rate was 26.1% with a median follow-up of 39 months (range 6-132 months). Regardless of the disease stage at diagnosis, combined chemotherapy and radiotherapy seemed to be more effective than chemotherapy alone in ocular adnexal MZL-MALT, as persistent complete remission was achieved in nine patients receiving combination therapy, while six of 14 patients treated with chemotherapy alone relapsed.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
0945-6317
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| pubmed:author |
pubmed-author:CapronFrédériqueF,
pubmed-author:CassouxNathalieN,
pubmed-author:CharlotteFrédéricF,
pubmed-author:DoghmiKamalK,
pubmed-author:DuMing-QingMQ,
pubmed-author:KujasMichèleM,
pubmed-author:LeblondVéroniqueV,
pubmed-author:LehoangPhucP,
pubmed-author:LesotAnnetteA,
pubmed-author:MansourGeorgeG,
pubmed-author:VignotNicoleN,
pubmed-author:YeHongtaoH
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| pubmed:issnType |
Print
|
| pubmed:volume |
448
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
506-16
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16323006-Adult,
pubmed-meshheading:16323006-Aged,
pubmed-meshheading:16323006-Aged, 80 and over,
pubmed-meshheading:16323006-Cell Nucleus,
pubmed-meshheading:16323006-Combined Modality Therapy,
pubmed-meshheading:16323006-Cytoplasm,
pubmed-meshheading:16323006-Diagnosis, Differential,
pubmed-meshheading:16323006-Eye Neoplasms,
pubmed-meshheading:16323006-Female,
pubmed-meshheading:16323006-Fluorescent Antibody Technique, Direct,
pubmed-meshheading:16323006-Germinal Center,
pubmed-meshheading:16323006-Humans,
pubmed-meshheading:16323006-Lymphoma, B-Cell, Marginal Zone,
pubmed-meshheading:16323006-Male,
pubmed-meshheading:16323006-Middle Aged,
pubmed-meshheading:16323006-Neoplasm Recurrence, Local,
pubmed-meshheading:16323006-Orbital Neoplasms,
pubmed-meshheading:16323006-Remission Induction,
pubmed-meshheading:16323006-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16323006-Translocation, Genetic,
pubmed-meshheading:16323006-Tumor Markers, Biological
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| pubmed:year |
2006
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| pubmed:articleTitle |
Ocular adnexal marginal zone B cell lymphoma: a clinical and pathologic study of 23 cases.
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| pubmed:affiliation |
Department of Pathology, Service d'Anatomie Pathologique, Hôpital Pitié-Salpêtrière, Boulevard de l'Hôpital, Paris, France. frederic.charlotte@psl.ap-hop-paris.fr
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| pubmed:publicationType |
Journal Article
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