| pubmed-article:16322791 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16322791 | lifeskim:mentions | umls-concept:C0023473 | lld:lifeskim |
| pubmed-article:16322791 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:16322791 | lifeskim:mentions | umls-concept:C1418214 | lld:lifeskim |
| pubmed-article:16322791 | lifeskim:mentions | umls-concept:C0544452 | lld:lifeskim |
| pubmed-article:16322791 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:16322791 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:16322791 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:16322791 | lifeskim:mentions | umls-concept:C0079380 | lld:lifeskim |
| pubmed-article:16322791 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:16322791 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:16322791 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:16322791 | lifeskim:mentions | umls-concept:C1515895 | lld:lifeskim |
| pubmed-article:16322791 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:16322791 | pubmed:dateCreated | 2005-12-2 | lld:pubmed |
| pubmed-article:16322791 | pubmed:abstractText | Minor histocompatibility antigens (mHAgs) constitute the targets of the graft-versus-leukemia response after HLA-identical allogeneic stem cell transplantation. Here, we have used genetic linkage analysis to identify a novel mHAg, designated lymphoid-restricted histocompatibility antigen-1 (LRH-1), which is encoded by the P2X5 gene and elicited an allogeneic CTL response in a patient with chronic myeloid leukemia after donor lymphocyte infusion. We demonstrate that immunogenicity for LRH-1 is due to differential protein expression in recipient and donor cells as a consequence of a homozygous frameshift polymorphism in the donor. Tetramer analysis showed that emergence of LRH-1-specific CD8+ cytotoxic T cells in peripheral blood and bone marrow correlated with complete remission of chronic myeloid leukemia. Furthermore, the restricted expression of LRH-1 in hematopoietic cells including leukemic CD34+ progenitor cells provides evidence of a role for LRH-1-specific CD8+ cytotoxic T cells in selective graft-versus-leukemia reactivity in the absence of severe graft-versus-host disease. These findings illustrate that the P2X5-encoded mHAg LRH-1 could be an attractive target for specific immunotherapy to treat hematological malignancies recurring after allogeneic stem cell transplantation. | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16322791 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16322791 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16322791 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16322791 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16322791 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:16322791 | pubmed:author | pubmed-author:LeppertMarkM | lld:pubmed |
| pubmed-article:16322791 | pubmed:author | pubmed-author:de WitteTheoT | lld:pubmed |
| pubmed-article:16322791 | pubmed:author | pubmed-author:KesterMichelM | lld:pubmed |
| pubmed-article:16322791 | pubmed:author | pubmed-author:DolstraHarryH | lld:pubmed |
| pubmed-article:16322791 | pubmed:author | pubmed-author:van de... | lld:pubmed |
| pubmed-article:16322791 | pubmed:author | pubmed-author:de... | lld:pubmed |
| pubmed-article:16322791 | pubmed:author | pubmed-author:MaasFransF | lld:pubmed |
| pubmed-article:16322791 | pubmed:author | pubmed-author:SchattenbergA... | lld:pubmed |
| pubmed-article:16322791 | pubmed:author | pubmed-author:BeekmanJeffre... | lld:pubmed |
| pubmed-article:16322791 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:16322791 | pubmed:author | pubmed-author:OtterudBrittB | lld:pubmed |
| pubmed-article:16322791 | pubmed:author | pubmed-author:WoestenenkRob... | lld:pubmed |
| pubmed-article:16322791 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16322791 | pubmed:volume | 115 | lld:pubmed |
| pubmed-article:16322791 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16322791 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16322791 | pubmed:pagination | 3506-16 | lld:pubmed |
| pubmed-article:16322791 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:16322791 | pubmed:meshHeading | pubmed-meshheading:16322791... | lld:pubmed |
| pubmed-article:16322791 | pubmed:meshHeading | pubmed-meshheading:16322791... | lld:pubmed |
| pubmed-article:16322791 | pubmed:meshHeading | pubmed-meshheading:16322791... | lld:pubmed |
