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rdf:type |
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lifeskim:mentions |
umls-concept:C0023473,
umls-concept:C0039195,
umls-concept:C0079380,
umls-concept:C0332281,
umls-concept:C0544452,
umls-concept:C0871261,
umls-concept:C1418214,
umls-concept:C1515895,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1882417,
umls-concept:C2911692
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pubmed:issue |
12
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pubmed:dateCreated |
2005-12-2
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pubmed:abstractText |
Minor histocompatibility antigens (mHAgs) constitute the targets of the graft-versus-leukemia response after HLA-identical allogeneic stem cell transplantation. Here, we have used genetic linkage analysis to identify a novel mHAg, designated lymphoid-restricted histocompatibility antigen-1 (LRH-1), which is encoded by the P2X5 gene and elicited an allogeneic CTL response in a patient with chronic myeloid leukemia after donor lymphocyte infusion. We demonstrate that immunogenicity for LRH-1 is due to differential protein expression in recipient and donor cells as a consequence of a homozygous frameshift polymorphism in the donor. Tetramer analysis showed that emergence of LRH-1-specific CD8+ cytotoxic T cells in peripheral blood and bone marrow correlated with complete remission of chronic myeloid leukemia. Furthermore, the restricted expression of LRH-1 in hematopoietic cells including leukemic CD34+ progenitor cells provides evidence of a role for LRH-1-specific CD8+ cytotoxic T cells in selective graft-versus-leukemia reactivity in the absence of severe graft-versus-host disease. These findings illustrate that the P2X5-encoded mHAg LRH-1 could be an attractive target for specific immunotherapy to treat hematological malignancies recurring after allogeneic stem cell transplantation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-10090944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-10411928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-10586024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-11086057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-11148223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-11171941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-11181995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-11333300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-11544309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-12045153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-12135428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-12135987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-12355426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-12601144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-12663445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-12714526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-12743171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-12842998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-14630824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-15122208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-15271400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-16322786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-1689009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-2184120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-2297567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-7539551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-7667640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-8091227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-8254189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-8786426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-8843602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-8992968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-9075928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-9208114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-9255626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-9368774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-9414125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-9461441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-9718341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-9722305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16322791-9892612
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD34,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/Chromium,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Fusion Proteins, bcr-abl,
http://linkedlifedata.com/resource/pubmed/chemical/Genetic Markers,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B*07:02 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B7 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/P2RX5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2X5,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-9738
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pubmed:author |
pubmed-author:BeekmanJeffrey MJM,
pubmed-author:DolstraHarryH,
pubmed-author:KesterMichelM,
pubmed-author:LeppertMarkM,
pubmed-author:MaasFransF,
pubmed-author:OtterudBrittB,
pubmed-author:SchattenbergAnton VAV,
pubmed-author:WoestenenkRobR,
pubmed-author:de RijkeBjörnB,
pubmed-author:de WitteTheoT,
pubmed-author:van Horssen-ZoetbroodAgnesA,
pubmed-author:van de Wiel-van KemenadeEllyE
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pubmed:issnType |
Print
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pubmed:volume |
115
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3506-16
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
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