Linked Life Data

16322316

Source:http://linkedlifedata.com/resource/pubmed/id/16322316

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
2005-12-2
pubmed:abstractText
Indole-3-carbinol has been proposed to induce apoptosis via a mechanism involving inhibition of protein kinase B (PKB) signaling in breast and prostate tumor cell lines. However, no functional data exist, and the effect of indole-3-carbinol on viability is known to be highly cell type specific. Here, we examine any requirement for PKB inhibition in induction of apoptosis by indole-3-carbinol in the MDA MB468 cell line using in vitro kinase assays, transfection, Western blotting, and flow cytometry. Comparison is also made with MCF10CA1 breast and PC3 prostate tumor cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1078-0432
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8521-7
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:16322316-Antioxidants, pubmed-meshheading:16322316-Apoptosis, pubmed-meshheading:16322316-Blotting, Western, pubmed-meshheading:16322316-Breast Neoplasms, pubmed-meshheading:16322316-Chromones, pubmed-meshheading:16322316-Drug Combinations, pubmed-meshheading:16322316-Enzyme Inhibitors, pubmed-meshheading:16322316-Epidermal Growth Factor, pubmed-meshheading:16322316-Female, pubmed-meshheading:16322316-Flow Cytometry, pubmed-meshheading:16322316-Humans, pubmed-meshheading:16322316-Immunoprecipitation, pubmed-meshheading:16322316-Indoles, pubmed-meshheading:16322316-Male, pubmed-meshheading:16322316-Morpholines, pubmed-meshheading:16322316-Phosphatidylinositol 3-Kinases, pubmed-meshheading:16322316-Phosphorylation, pubmed-meshheading:16322316-Prostatic Neoplasms, pubmed-meshheading:16322316-Signal Transduction, pubmed-meshheading:16322316-Transfection, pubmed-meshheading:16322316-Tumor Cells, Cultured
pubmed:year
2005
pubmed:articleTitle
Inhibition of phosphatidylinositol 3-kinase/protein kinase B signaling is not sufficient to account for indole-3-carbinol-induced apoptosis in some breast and prostate tumor cells.
pubmed:affiliation
Cancer Biomarkers and Prevention Group, Department of Biochemistry and Cancer Studies, Biocentre, University of Leicester, Leicester, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't