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rdf:type |
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lifeskim:mentions |
umls-concept:C0009015,
umls-concept:C0012860,
umls-concept:C0017337,
umls-concept:C0033684,
umls-concept:C0079419,
umls-concept:C0205314,
umls-concept:C0679622,
umls-concept:C0685938,
umls-concept:C0805701,
umls-concept:C1428754,
umls-concept:C1514562,
umls-concept:C1880022
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pubmed:issue |
23
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pubmed:dateCreated |
2005-12-2
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pubmed:abstractText |
We have identified a p53 and DNA damage-regulated gene that encodes a novel IQ motif protein, which we have named p53 and DNA damage-regulated IQ motif protein (PIQ). PIQ has two isoforms, long (PIQ-L) and short (PIQ-S), and both bind to calmodulin in the presence and absence of calcium. PIQ expression is down-regulated by p53 and DNA damage-inducing agents, whereas PIQ itself represses the expression of p53 up-regulated modulator of apoptosis that is a key mediator of p53-induced apoptosis. Thus, PIQ is a novel protein that may function to bridge a crosstalk between p53 and calmodulin-regulated cellular processes. We further show that PIQ expression is up-regulated in a number of primary colorectal and gastric tumors when compared with matching normal tissues, suggesting that PIQ may be involved in tumorigenesis and could serve as a valuable diagnostic/prognostic marker for gastrointestinal tumors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/BBC3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Calmodulin,
http://linkedlifedata.com/resource/pubmed/chemical/Calmodulin-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/IQCB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TP53 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0008-5472
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10725-33
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16322217-Amino Acid Sequence,
pubmed-meshheading:16322217-Apoptosis Regulatory Proteins,
pubmed-meshheading:16322217-Calmodulin,
pubmed-meshheading:16322217-Calmodulin-Binding Proteins,
pubmed-meshheading:16322217-Cell Line, Tumor,
pubmed-meshheading:16322217-Cloning, Molecular,
pubmed-meshheading:16322217-Colorectal Neoplasms,
pubmed-meshheading:16322217-Consensus Sequence,
pubmed-meshheading:16322217-DNA Damage,
pubmed-meshheading:16322217-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16322217-HCT116 Cells,
pubmed-meshheading:16322217-Humans,
pubmed-meshheading:16322217-Lung Neoplasms,
pubmed-meshheading:16322217-Molecular Sequence Data,
pubmed-meshheading:16322217-Proto-Oncogene Proteins,
pubmed-meshheading:16322217-Sequence Alignment,
pubmed-meshheading:16322217-Stomach Neoplasms,
pubmed-meshheading:16322217-Transfection,
pubmed-meshheading:16322217-Tumor Suppressor Protein p53
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pubmed:year |
2005
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pubmed:articleTitle |
Cloning and characterization of a p53 and DNA damage down-regulated gene PIQ that codes for a novel calmodulin-binding IQ motif protein and is up-regulated in gastrointestinal cancers.
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pubmed:affiliation |
Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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