rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
5
|
pubmed:dateCreated |
2006-1-30
|
pubmed:abstractText |
Netrins, a family of secreted molecules, play important roles in axon pathfinding during nervous system development. Although phosphatidylinositol signaling has been implicated in this event, how netrin-1 regulates phosphatidylinositol signaling remains poorly understood. Here we provide evidence that netrin-1 stimulates phosphatidylinositol bisphosphate hydrolysis in cortical neurons. This event appears to be mediated by DCC (deleted in colorectal cancer), but not neogenin or Unc5h2. Netrin-1 induces phospholipase Cgamma (PLCgamma) tyrosine phosphorylation. Inhibition of PLC activity attenuates netrin-1-induced cortical neurite outgrowth. These results suggest that netrin-1 regulates phosphatidylinositol turnover and demonstrate a crucial role of PLC signaling in netrin-1-induced neurite elongation.
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pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0021-9258
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
3
|
pubmed:volume |
281
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2605-11
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:16321979-Animals,
pubmed-meshheading:16321979-Cells, Cultured,
pubmed-meshheading:16321979-Cerebral Cortex,
pubmed-meshheading:16321979-Humans,
pubmed-meshheading:16321979-Mice,
pubmed-meshheading:16321979-Nerve Growth Factors,
pubmed-meshheading:16321979-Neurites,
pubmed-meshheading:16321979-Neurons,
pubmed-meshheading:16321979-Phosphatidylinositol Phosphates,
pubmed-meshheading:16321979-Rats,
pubmed-meshheading:16321979-Rats, Sprague-Dawley,
pubmed-meshheading:16321979-Receptors, Cell Surface,
pubmed-meshheading:16321979-Signal Transduction,
pubmed-meshheading:16321979-Tumor Suppressor Proteins,
pubmed-meshheading:16321979-Type C Phospholipases
|
pubmed:year |
2006
|
pubmed:articleTitle |
DCC-dependent phospholipase C signaling in netrin-1-induced neurite elongation.
|
pubmed:affiliation |
Institute of Molecular Medicine & Genomics and Department of Neurology, Medical College of Georgia, Augusta, Georgia 30809, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|