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pubmed-article:16321962pubmed:abstractTextThermoplasma acidophilum is sensitive to the antibiotic drug novobiocin, which inhibits DNA gyrase. We characterized DNA gyrases from T. acidophilum strains in vitro. The DNA gyrase from a novobiocin-resistant strain and an engineered mutant were less sensitive to novobiocin. The novobiocin-resistant gyrase genes might serve as T. acidophilum genetic markers.lld:pubmed
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pubmed-article:16321962pubmed:articleTitleCharacterization of the DNA gyrase from the thermoacidophilic archaeon Thermoplasma acidophilum.lld:pubmed
pubmed-article:16321962pubmed:affiliationDepartment of Molecular Biology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.lld:pubmed
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