16321962

Source:http://linkedlifedata.com/resource/pubmed/id/16321962

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003732, umls-concept:C0949782, umls-concept:C0995938, umls-concept:C1880022
pubmed:issue	24
pubmed:dateCreated	2005-12-2
pubmed:abstractText	Thermoplasma acidophilum is sensitive to the antibiotic drug novobiocin, which inhibits DNA gyrase. We characterized DNA gyrases from T. acidophilum strains in vitro. The DNA gyrase from a novobiocin-resistant strain and an engineered mutant were less sensitive to novobiocin. The novobiocin-resistant gyrase genes might serve as T. acidophilum genetic markers.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/16321962-11029001, http://linkedlifedata.com/resource/pubmed/commentcorrection/16321962-11395412, http://linkedlifedata.com/resource/pubmed/commentcorrection/16321962-12509418, http://linkedlifedata.com/resource/pubmed/commentcorrection/16321962-12596227, http://linkedlifedata.com/resource/pubmed/commentcorrection/16321962-12804, http://linkedlifedata.com/resource/pubmed/commentcorrection/16321962-1323022, http://linkedlifedata.com/resource/pubmed/commentcorrection/16321962-15105144, http://linkedlifedata.com/resource/pubmed/commentcorrection/16321962-1646964, http://linkedlifedata.com/resource/pubmed/commentcorrection/16321962-1657531, http://linkedlifedata.com/resource/pubmed/commentcorrection/16321962-1846146, http://linkedlifedata.com/resource/pubmed/commentcorrection/16321962-186775, http://linkedlifedata.com/resource/pubmed/commentcorrection/16321962-2112744, http://linkedlifedata.com/resource/pubmed/commentcorrection/16321962-5481857, http://linkedlifedata.com/resource/pubmed/commentcorrection/16321962-7608096, http://linkedlifedata.com/resource/pubmed/commentcorrection/16321962-794878, http://linkedlifedata.com/resource/pubmed/commentcorrection/16321962-7961685, http://linkedlifedata.com/resource/pubmed/commentcorrection/16321962-8940171, http://linkedlifedata.com/resource/pubmed/commentcorrection/16321962-9031142, http://linkedlifedata.com/resource/pubmed/commentcorrection/16321962-9396791
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/2985120R
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents, http://linkedlifedata.com/resource/pubmed/chemical/DNA, Superhelical, http://linkedlifedata.com/resource/pubmed/chemical/DNA Gyrase, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Novobiocin, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
pubmed:status	MEDLINE
pubmed:month	Dec
pubmed:issn	0021-9193
pubmed:author	pubmed-author:YamagishiAkihikoA, pubmed-author:YamashiroKanK
pubmed:issnType	Print
pubmed:volume	187
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	8531-6
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:16321962-Amino Acid Sequence, pubmed-meshheading:16321962-Anti-Bacterial Agents, pubmed-meshheading:16321962-DNA, Superhelical, pubmed-meshheading:16321962-DNA Gyrase, pubmed-meshheading:16321962-Drug Resistance, Microbial, pubmed-meshheading:16321962-Enzyme Inhibitors, pubmed-meshheading:16321962-Genes, Archaeal, pubmed-meshheading:16321962-Molecular Sequence Data, pubmed-meshheading:16321962-Novobiocin, pubmed-meshheading:16321962-Recombinant Proteins, pubmed-meshheading:16321962-Sequence Homology, pubmed-meshheading:16321962-Thermoplasma
pubmed:year	2005
pubmed:articleTitle	Characterization of the DNA gyrase from the thermoacidophilic archaeon Thermoplasma acidophilum.
pubmed:affiliation	Department of Molecular Biology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't