| pubmed-article:16321427 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16321427 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:16321427 | lifeskim:mentions | umls-concept:C0026339 | lld:lifeskim |
| pubmed-article:16321427 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:16321427 | lifeskim:mentions | umls-concept:C0205276 | lld:lifeskim |
| pubmed-article:16321427 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:16321427 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:16321427 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:16321427 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16321427 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:16321427 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:16321427 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:16321427 | pubmed:issue | 1-3 | lld:pubmed |
| pubmed-article:16321427 | pubmed:dateCreated | 2006-2-1 | lld:pubmed |
| pubmed-article:16321427 | pubmed:abstractText | Calcium-induced-calcium-release in cardiac myocytes is the release of Ca(2+) from the sarcoplasmic reticulum (SR) triggered by Ca(2+) entering the cell through L-type Ca(2+) channels. The Ca(2+) is released through ryanodine receptors which 'sense' local [Ca(2+)] in the small region (the diadic space) positioned between the t-tubules and the SR. The length-scale of a single diad is of the order of 10nm and the diffusion time-scale is of order of 1 micros with each cell containing approximately 10,000 diadic spaces which act independently. However, typically one is interested in Ca(2+) currents at the whole cell level and higher. This is a multi-scale problem and cannot be solved by direct computation. In this paper we develop a general framework for deriving approximate solutions of these models. | lld:pubmed |
| pubmed-article:16321427 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16321427 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16321427 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16321427 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16321427 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16321427 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16321427 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16321427 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16321427 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16321427 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16321427 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16321427 | pubmed:issn | 0079-6107 | lld:pubmed |
| pubmed-article:16321427 | pubmed:author | pubmed-author:WinslowR LRL | lld:pubmed |
| pubmed-article:16321427 | pubmed:author | pubmed-author:GreensteinJ... | lld:pubmed |
| pubmed-article:16321427 | pubmed:author | pubmed-author:HinchRR | lld:pubmed |
| pubmed-article:16321427 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16321427 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:16321427 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16321427 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16321427 | pubmed:pagination | 136-50 | lld:pubmed |
| pubmed-article:16321427 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:16321427 | pubmed:meshHeading | pubmed-meshheading:16321427... | lld:pubmed |
| pubmed-article:16321427 | pubmed:meshHeading | pubmed-meshheading:16321427... | lld:pubmed |
| pubmed-article:16321427 | pubmed:meshHeading | pubmed-meshheading:16321427... | lld:pubmed |
| pubmed-article:16321427 | pubmed:meshHeading | pubmed-meshheading:16321427... | lld:pubmed |
| pubmed-article:16321427 | pubmed:meshHeading | pubmed-meshheading:16321427... | lld:pubmed |
| pubmed-article:16321427 | pubmed:meshHeading | pubmed-meshheading:16321427... | lld:pubmed |
| pubmed-article:16321427 | pubmed:meshHeading | pubmed-meshheading:16321427... | lld:pubmed |
| pubmed-article:16321427 | pubmed:meshHeading | pubmed-meshheading:16321427... | lld:pubmed |
| pubmed-article:16321427 | pubmed:meshHeading | pubmed-meshheading:16321427... | lld:pubmed |
| pubmed-article:16321427 | pubmed:articleTitle | Multi-scale models of local control of calcium induced calcium release. | lld:pubmed |
| pubmed-article:16321427 | pubmed:affiliation | Center for Cardiovascular Bioinformatics and Modeling, The John's Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, MD, USA. | lld:pubmed |
| pubmed-article:16321427 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16321427 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:16321427 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16321427 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16321427 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16321427 | lld:pubmed |
