Linked Life Data

16321427

Source:http://linkedlifedata.com/resource/pubmed/id/16321427

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
2006-2-1
pubmed:abstractText
Calcium-induced-calcium-release in cardiac myocytes is the release of Ca(2+) from the sarcoplasmic reticulum (SR) triggered by Ca(2+) entering the cell through L-type Ca(2+) channels. The Ca(2+) is released through ryanodine receptors which 'sense' local [Ca(2+)] in the small region (the diadic space) positioned between the t-tubules and the SR. The length-scale of a single diad is of the order of 10nm and the diffusion time-scale is of order of 1 micros with each cell containing approximately 10,000 diadic spaces which act independently. However, typically one is interested in Ca(2+) currents at the whole cell level and higher. This is a multi-scale problem and cannot be solved by direct computation. In this paper we develop a general framework for deriving approximate solutions of these models.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0079-6107
pubmed:author
pubmed:issnType
Print
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
136-50
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Multi-scale models of local control of calcium induced calcium release.
pubmed:affiliation
Center for Cardiovascular Bioinformatics and Modeling, The John's Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, MD, USA.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural