Linked Life Data

1632110

Source:http://linkedlifedata.com/resource/pubmed/id/1632110

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-8-14
pubmed:abstractText
1. The high-affinity and total activities of 7-methoxycoumarin O-demethylase and of 7-ethoxycoumarin O-deethylase were measured in liver microsomes isolated from rats treated with prototypic inducers belonging to the main classes of microsomal enzyme inducers currently recognized. 2. Each inducer (with the exception of clofibrate which was ineffective) produced a unique induction profile, indicating the possibility of using these two enzymes, each measured at two substrate concentrations, for characterization of the inducing potential of novel xenobiotics. 3. Differences between p,p'-DDT and phenobarbitone in the induction profiles indicate that DDT may not be a pure 'phenobarbitone-type' inducer as has been proposed hitherto.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0049-8254
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
211-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Differentiation of cytochrome P-450 inducers on the basis of 7-alkoxycoumarin O-dealkylase activities.
pubmed:affiliation
Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't