Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-12-6
pubmed:abstractText
In mammals, the transcription factor Nurr1 is expressed early in development and continues to be detectable throughout the organism's lifetime. Nurr1 is involved in the establishment and maintenance of the dopaminergic phenotype within specific central nervous system neuronal subpopulations including the nigrostriatal dopamine system. This protein is reduced over the course of normal aging, which is a major risk factor for Parkinson's disease (PD). However, whether Nurr1 expression is affected by PD has not been documented. The present study examined the role of Nurr1 in the maintenance of the dopaminergic phenotype within neurons in substantia nigra in PD compared with patients with diagnoses of progressive supranuclear palsy (PSP) or Alzheimer's disease (AD) or age-matched-matched controls. In PD, the optical density (OD) of Nurr1 immunofluorescence was significantly decreased in nigral neurons containing alpha-synuclein-immunoreactive inclusions. Similarly, the OD of Nurr1 immunofluorescence intensity in the nigra of AD cases was decreased in neurons with neurofibrillary tangles (NFTs). In contrast to PD and AD, the OD of Nurr1 immunofluorescence intensity was severely decreased in the neurons with or without NFTs in PSP cases. Decline of Nurr1-ir neuronal number and OD was observed within substantia nigra (SN) neurons in PD but not within hippocampal neurons. The decline in Nurr1-ir expression was correlated with loss of tyrosine hydroxylase immunofluorescence across the four groups. These data demonstrate that Nurr1 deficiency in dopaminergic neurons is associated with the intracellular pathology in both synucleinopathies and tauopathies.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-10537083, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-10678833, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-10821633, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-10878819, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-11052933, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-11074347, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-11220740, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-11238740, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-11494257, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-11749040, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-12077607, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-12209851, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-12385813, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-12498954, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-12678688, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-12694388, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-12716427, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-12819014, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-12846972, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-12915123, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-14593166, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-14602969, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-14626695, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-15389895, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-15681811, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-1793176, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-1975219, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-3430576, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-7693894, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-8103078, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-9092472, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-9278044, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-9520484, http://linkedlifedata.com/resource/pubmed/commentcorrection/16320253-9608532
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0021-9967
pubmed:author
pubmed:copyrightInfo
Copyright 2005 Wiley-Liss, Inc
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
494
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
495-514
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed-meshheading:16320253-Aged, pubmed-meshheading:16320253-Aged, 80 and over, pubmed-meshheading:16320253-Alzheimer Disease, pubmed-meshheading:16320253-Cell Count, pubmed-meshheading:16320253-DNA-Binding Proteins, pubmed-meshheading:16320253-Dopamine, pubmed-meshheading:16320253-Female, pubmed-meshheading:16320253-Humans, pubmed-meshheading:16320253-Immunohistochemistry, pubmed-meshheading:16320253-Male, pubmed-meshheading:16320253-Matched-Pair Analysis, pubmed-meshheading:16320253-Middle Aged, pubmed-meshheading:16320253-Neurofibrillary Tangles, pubmed-meshheading:16320253-Neurons, pubmed-meshheading:16320253-Nuclear Receptor Subfamily 4, Group A, Member 2, pubmed-meshheading:16320253-Parkinson Disease, pubmed-meshheading:16320253-Reference Values, pubmed-meshheading:16320253-Substantia Nigra, pubmed-meshheading:16320253-Supranuclear Palsy, Progressive, pubmed-meshheading:16320253-Tissue Distribution, pubmed-meshheading:16320253-Transcription Factors, pubmed-meshheading:16320253-Tyrosine 3-Monooxygenase, pubmed-meshheading:16320253-alpha-Synuclein
pubmed:year
2006
More...