Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7068
pubmed:dateCreated
2005-12-1
pubmed:databankReference
pubmed:abstractText
Lens-specific aquaporin-0 (AQP0) functions as a specific water pore and forms the thin junctions between fibre cells. Here we describe a 1.9 A resolution structure of junctional AQP0, determined by electron crystallography of double-layered two-dimensional crystals. Comparison of junctional and non-junctional AQP0 structures shows that junction formation depends on a conformational switch in an extracellular loop, which may result from cleavage of the cytoplasmic amino and carboxy termini. In the centre of the water pathway, the closed pore in junctional AQP0 retains only three water molecules, which are too widely spaced to form hydrogen bonds with each other. Packing interactions between AQP0 tetramers in the crystalline array are mediated by lipid molecules, which assume preferred conformations. We were therefore able to build an atomic model for the lipid bilayer surrounding the AQP0 tetramers, and we describe lipid-protein interactions.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-10024456, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-10452895, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-10634618, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-11001937, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-11034202, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-11039922, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-11053241, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-11090476, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-11171962, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-11532456, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-11743202, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-11780053, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-11964478, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-12096044, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-12676560, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-14578404, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-14598384, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-14691544, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-15078916, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-15099574, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-15141214, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-15274640, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-15351655, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-15377788, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-15519305, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-15519309, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-15519316, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-15665131, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-15837176, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-16084383, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-16319869, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-2025413, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-3949474, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-436981, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-7068755, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-7358167, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-8563764, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-9242906, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-9757107, http://linkedlifedata.com/resource/pubmed/commentcorrection/16319884-9949765
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1476-4687
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
438
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
633-8
pubmed:dateRevised
2011-2-9
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Lipid-protein interactions in double-layered two-dimensional AQP0 crystals.
pubmed:affiliation
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural