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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1992-8-20
|
| pubmed:abstractText |
With more than 300 different variants reported, the human enzyme glucose-6-phosphate dehydrogenase (G6PD; EC 1.1.1.49) is one of the most polymorphic proteins known. An estimated 400 million people throughout the world are deficient in G6PD; numerous lines of evidence indicate that this is because female heterozygotes have a selective advantage in malaria infections. The cloning of the G6PD gene has made it possible to clarify the molecular basis underlying this enzyme deficiency and polymorphism.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0168-9525
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
8
|
| pubmed:geneSymbol |
G6PD
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
138-43
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:1631957-Amino Acid Sequence,
pubmed-meshheading:1631957-Biological Evolution,
pubmed-meshheading:1631957-Glucosephosphate Dehydrogenase Deficiency,
pubmed-meshheading:1631957-Humans,
pubmed-meshheading:1631957-Malaria, Falciparum,
pubmed-meshheading:1631957-Molecular Sequence Data,
pubmed-meshheading:1631957-Mutation,
pubmed-meshheading:1631957-Selection, Genetic
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
The molecular basis of glucose-6-phosphate dehydrogenase deficiency.
|
| pubmed:affiliation |
Department of Haematology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
|
| pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|