| pubmed-article:16316998 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16316998 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:16316998 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:16316998 | lifeskim:mentions | umls-concept:C0001461 | lld:lifeskim |
| pubmed-article:16316998 | lifeskim:mentions | umls-concept:C1508748 | lld:lifeskim |
| pubmed-article:16316998 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:16316998 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16316998 | pubmed:dateCreated | 2006-1-30 | lld:pubmed |
| pubmed-article:16316998 | pubmed:abstractText | Stimulation of Jurkat T cells by high concentrations of concanavalin A (ConA) induced an elevation of the endogenous adenosine diphosphoribose (ADPR) concentration and an inward current significantly different from the Ca2+ release-activated Ca2+ current (I(CRAC)). Electrophysiological characterization and activation of a similar current by infusion of ADPR indicated that the ConA-induced current is carried by TRPM2. Expression of TRPM2 in the plasma membrane of Jurkat T cells was demonstrated by reverse transcription-PCR, Western blot, and immunofluorescence. Inhibition of ADPR formation reduced ConA-mediated, but not store-operated, Ca2+ entry and prevented ConA-induced cell death of Jurkat cells. Moreover, gene silencing of TRPM2 abolished the ADPR- and ConA-mediated inward current. Thus, ADPR is a novel second messenger significantly involved in ConA-mediated cell death in T cells. | lld:pubmed |
| pubmed-article:16316998 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16316998 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16316998 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16316998 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16316998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16316998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16316998 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16316998 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16316998 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:16316998 | pubmed:author | pubmed-author:HeinerInkaI | lld:pubmed |
| pubmed-article:16316998 | pubmed:author | pubmed-author:GuseAndreas... | lld:pubmed |
| pubmed-article:16316998 | pubmed:author | pubmed-author:WeberKarinK | lld:pubmed |
| pubmed-article:16316998 | pubmed:author | pubmed-author:OppenheimerNo... | lld:pubmed |
| pubmed-article:16316998 | pubmed:author | pubmed-author:SchwarzJürgen... | lld:pubmed |
| pubmed-article:16316998 | pubmed:author | pubmed-author:LanghorstMatt... | lld:pubmed |
| pubmed-article:16316998 | pubmed:author | pubmed-author:FliegertRalfR | lld:pubmed |
| pubmed-article:16316998 | pubmed:author | pubmed-author:GasserAndreas... | lld:pubmed |
| pubmed-article:16316998 | pubmed:author | pubmed-author:GlassmeierGün... | lld:pubmed |
| pubmed-article:16316998 | pubmed:author | pubmed-author:MeinkeStephan... | lld:pubmed |
| pubmed-article:16316998 | pubmed:author | pubmed-author:HeinDörteD | lld:pubmed |
| pubmed-article:16316998 | pubmed:author | pubmed-author:KrügerSylviaS | lld:pubmed |
| pubmed-article:16316998 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16316998 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:16316998 | pubmed:volume | 281 | lld:pubmed |
| pubmed-article:16316998 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16316998 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16316998 | pubmed:pagination | 2489-96 | lld:pubmed |
| pubmed-article:16316998 | pubmed:dateRevised | 2007-8-13 | lld:pubmed |
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| pubmed-article:16316998 | pubmed:meshHeading | pubmed-meshheading:16316998... | lld:pubmed |
| pubmed-article:16316998 | pubmed:meshHeading | pubmed-meshheading:16316998... | lld:pubmed |
| pubmed-article:16316998 | pubmed:meshHeading | pubmed-meshheading:16316998... | lld:pubmed |
| pubmed-article:16316998 | pubmed:meshHeading | pubmed-meshheading:16316998... | lld:pubmed |
| pubmed-article:16316998 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16316998 | pubmed:articleTitle | Activation of T cell calcium influx by the second messenger ADP-ribose. | lld:pubmed |
| pubmed-article:16316998 | pubmed:affiliation | University Medical Center Hamburg-Eppendorf, Center of Experimental Medicine, Institute of Biochemistry and Molecular Biology I: Cellular Signal Transduction. | lld:pubmed |
| pubmed-article:16316998 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16316998 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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