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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2005-11-30
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pubmed:abstractText |
We previously demonstrated that chronic hypoxia has pivotal roles in the progression of tubulointerstitial injury from the early stage of the uninephrectomized Thy1 nephritis model. We have also shown that pretreatment of cobalt confers renoprotection in the ischemia/reperfusion (I/R) injury, in association with the up-regulation of hypoxia-inducible factor (HIF)-regulated genes. Here, we tested the hypothesis that cobalt administration not only attenuates acute ischemic insult, but also ameliorates tubulointerstitial injury secondary to chronic hypoxia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2714-25
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16316346-Animals,
pubmed-meshheading:16316346-Anoxia,
pubmed-meshheading:16316346-Antibodies,
pubmed-meshheading:16316346-Antimutagenic Agents,
pubmed-meshheading:16316346-Apoptosis,
pubmed-meshheading:16316346-Capillaries,
pubmed-meshheading:16316346-Cobalt,
pubmed-meshheading:16316346-Erythropoietin,
pubmed-meshheading:16316346-Gene Expression Regulation,
pubmed-meshheading:16316346-Glomerulonephritis,
pubmed-meshheading:16316346-Glomerulosclerosis, Focal Segmental,
pubmed-meshheading:16316346-Heme Oxygenase-1,
pubmed-meshheading:16316346-Hypoxia-Inducible Factor 1,
pubmed-meshheading:16316346-In Situ Nick-End Labeling,
pubmed-meshheading:16316346-Isoantibodies,
pubmed-meshheading:16316346-Kidney Tubules,
pubmed-meshheading:16316346-Male,
pubmed-meshheading:16316346-Nephrectomy,
pubmed-meshheading:16316346-Rats,
pubmed-meshheading:16316346-Rats, Sprague-Dawley,
pubmed-meshheading:16316346-Renin-Angiotensin System,
pubmed-meshheading:16316346-Reperfusion Injury,
pubmed-meshheading:16316346-Vascular Endothelial Growth Factor A
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pubmed:year |
2005
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pubmed:articleTitle |
Induction of protective genes by cobalt ameliorates tubulointerstitial injury in the progressive Thy1 nephritis.
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pubmed:affiliation |
Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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