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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2005-11-30
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pubmed:abstractText |
Nephrotic syndrome is a common kidney disease in both children and adults that is characterized by dramatic structural changes in the actin-rich foot processes of glomerular podocytes. Although glucocorticoids are the primary treatment for nephrotic syndrome, neither the target cell nor mechanism of action of glucocorticoids in nephrotic syndrome is known. For the last 30 years glucocorticoids have been presumed to act by reducing the release of soluble mediators of disease by circulating lymphocytes. In contrast, we hypothesized that glucocorticoids exert their beneficial effects in nephrotic syndrome by direct action on podocytes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antibiotics, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Bicyclo Compounds, Heterocyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochalasin D,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Hormone Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Mifepristone,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleic Acid Synthesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Polymers,
http://linkedlifedata.com/resource/pubmed/chemical/Puromycin Aminonucleoside,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazolidines,
http://linkedlifedata.com/resource/pubmed/chemical/latrunculin A,
http://linkedlifedata.com/resource/pubmed/chemical/rho GTP-Binding Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2473-83
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16316324-Actin Cytoskeleton,
pubmed-meshheading:16316324-Animals,
pubmed-meshheading:16316324-Anti-Inflammatory Agents,
pubmed-meshheading:16316324-Antibiotics, Antineoplastic,
pubmed-meshheading:16316324-Bicyclo Compounds, Heterocyclic,
pubmed-meshheading:16316324-Cell Line, Transformed,
pubmed-meshheading:16316324-Cell Survival,
pubmed-meshheading:16316324-Cytochalasin D,
pubmed-meshheading:16316324-Dexamethasone,
pubmed-meshheading:16316324-Drug Interactions,
pubmed-meshheading:16316324-Hormone Antagonists,
pubmed-meshheading:16316324-Mesangial Cells,
pubmed-meshheading:16316324-Mice,
pubmed-meshheading:16316324-Mifepristone,
pubmed-meshheading:16316324-NIH 3T3 Cells,
pubmed-meshheading:16316324-Nucleic Acid Synthesis Inhibitors,
pubmed-meshheading:16316324-Podocytes,
pubmed-meshheading:16316324-Polymers,
pubmed-meshheading:16316324-Puromycin Aminonucleoside,
pubmed-meshheading:16316324-Thiazoles,
pubmed-meshheading:16316324-Thiazolidines,
pubmed-meshheading:16316324-rho GTP-Binding Proteins
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pubmed:year |
2005
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pubmed:articleTitle |
Glucocorticoids protect and enhance recovery of cultured murine podocytes via actin filament stabilization.
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pubmed:affiliation |
Pediatric Nephrology Division, University of Michigan, Ann Arbor, MI 48109, USA. rransom@umich.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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