|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2006-3-17
|
|
pubmed:abstractText |
Owing to their agonist action on dopaminergic systems, cannabinoids may play a major role in substance dependency and schizophrenia. We examined the (AAT)n triplet repeat polymorphism nearby the CNR1 gene, which encodes human cannabinoid (CB1) receptor, in a male Afro-Caribbean population. The allelic and genotypic distributions were significantly different in non-schizophrenic cocaine dependents (n = 97), schizophrenic cocaine dependents (n = 45) and matched controls (n = 88) (P < 10(-4)). The frequency of the (AAT)12 repeat allele was increased in non-schizophrenic cocaine dependents and schizophrenic cocaine dependents vs controls (25.3 and 26.7 vs 5.7%) (P < 10(-4)). Our results support that the (AAT)n polymorphism nearby the CNR1 gene could be associated with predisposition to cocaine dependency.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1470-269X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
6
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
126-30
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:16314880-Adult,
pubmed-meshheading:16314880-African Continental Ancestry Group,
pubmed-meshheading:16314880-Animals,
pubmed-meshheading:16314880-Cell Adhesion Molecules, Neuronal,
pubmed-meshheading:16314880-Cocaine-Related Disorders,
pubmed-meshheading:16314880-DNA,
pubmed-meshheading:16314880-Female,
pubmed-meshheading:16314880-Gene Frequency,
pubmed-meshheading:16314880-Humans,
pubmed-meshheading:16314880-Male,
pubmed-meshheading:16314880-Martinique,
pubmed-meshheading:16314880-Neuropeptides,
pubmed-meshheading:16314880-Polymorphism, Genetic,
pubmed-meshheading:16314880-Receptors, Cell Surface,
pubmed-meshheading:16314880-Schizophrenia,
pubmed-meshheading:16314880-Trinucleotide Repeats
|
|
pubmed:articleTitle |
(AAT)n repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population.
|
|
pubmed:affiliation |
Department of Psychiatry, University Hospital of Fort de France, Fort de France, Martinique, French West Indies. ballon@informatique2000.fr
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
