rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2006-1-26
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pubmed:abstractText |
The Wnt/beta-catenin signaling pathway is activated in many human hepatocellular carcinomas (HCC). We tried to identify the genes involved in carcinogenesis and progression of HCC with beta-catenin mutations. We used PCR-based subtractive hybridization to compare gene expression between malignant and benign components of a human HCC occurring in pre-existing adenoma activated for beta-catenin. Two of the genes identified belong to the Regenerating gene (REG) family. They encode the Regenerating islet-derived 3 alpha (REG3A/HIP/PAP/REG-III) and 1 alpha (REG1A) proteins, both involved in liver and pancreatic regeneration and proliferation. Using siRNA directed against beta-catenin, we demonstrated that REG3A is a target of beta-catenin signaling in Huh7 hepatoma cells. The upregulation of REG3A and REG1A expression is significantly correlated to the beta-catenin status in 42 HCC and 28 hepatoblastomas characterized for their beta-catenin status. Thus, we report strong evidence that both genes are downstream targets of the Wnt pathway during liver tumorigenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Lithostathine,
http://linkedlifedata.com/resource/pubmed/chemical/REG1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/pancreatitis-associated protein
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0950-9232
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
599-608
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pubmed:dateRevised |
2010-2-8
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pubmed:meshHeading |
pubmed-meshheading:16314847-Adenoma,
pubmed-meshheading:16314847-Adult,
pubmed-meshheading:16314847-Antigens, Neoplasm,
pubmed-meshheading:16314847-Carcinoma, Hepatocellular,
pubmed-meshheading:16314847-Cell Line, Tumor,
pubmed-meshheading:16314847-Colonic Neoplasms,
pubmed-meshheading:16314847-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16314847-Hepatoblastoma,
pubmed-meshheading:16314847-Humans,
pubmed-meshheading:16314847-Lectins, C-Type,
pubmed-meshheading:16314847-Lithostathine,
pubmed-meshheading:16314847-Liver Neoplasms,
pubmed-meshheading:16314847-Male,
pubmed-meshheading:16314847-Mutation,
pubmed-meshheading:16314847-Signal Transduction,
pubmed-meshheading:16314847-Tumor Markers, Biological,
pubmed-meshheading:16314847-beta Catenin
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pubmed:year |
2006
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pubmed:articleTitle |
Overexpression of regenerating islet-derived 1 alpha and 3 alpha genes in human primary liver tumors with beta-catenin mutations.
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pubmed:affiliation |
Département GDPM, INSERM U-567, CNRS UMR 8104, Institut Cochin, Université Paris 5, France. cavard@cochin.inserm.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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