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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2005-12-6
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pubmed:abstractText |
Sulfatide derived from the myelin stimulates a distinct population of CD1d-restricted natural killer T (NKT) cells. Cis-tetracosenoyl sulfatide is one of the immunodominant species in myelin as identified by proliferation, cytokine secretion, and CD1d tetramer staining. The crystal structure of mouse CD1d in complex with cis-tetracosenoyl sulfatide at 1.9 A resolution reveals that the longer cis-tetracosenoyl fatty acid chain fully occupies the A' pocket of the CD1d binding groove, whereas the sphingosine chain fills up the F' pocket. A precise hydrogen bond network in the center of the binding groove orients and positions the ceramide backbone for insertion of the lipid tails in their respective pockets. The 3'-sulfated galactose headgroup is highly exposed for presentation to the T cell receptor and projects up and away from the binding pocket due to its beta linkage, compared with the more intimate binding of the alpha-glactosyl ceramide headgroup to CD1d. These structure and binding data on sulfatide presentation by CD1d have important implications for the design of therapeutics that target T cells reactive for myelin glycolipids in autoimmune diseases of the central nervous system.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-10359121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-11134934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-11748280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-11956292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-12118248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-12557186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-12658269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-12833155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-12847141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-14684827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-14716313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-14764708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-1481629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-15032598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-15051763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-15272157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-15299926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-15539565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-15545985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-15665086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-15723809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-15771584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-15791257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-15791258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-15864273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-15891404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-15928680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-16002697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-16007090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-16007091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-16034430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-16212488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-1758883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-2025413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-2562390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-2802541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-5873369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-7077353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-7546402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-8027366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-8741126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-8765339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-9219685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16314439-9374463
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
202
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1517-26
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16314439-Animals,
pubmed-meshheading:16314439-Mice,
pubmed-meshheading:16314439-Cattle,
pubmed-meshheading:16314439-Female,
pubmed-meshheading:16314439-Crystallography, X-Ray,
pubmed-meshheading:16314439-Myelin Sheath,
pubmed-meshheading:16314439-Galactosylceramides,
pubmed-meshheading:16314439-Sulfoglycosphingolipids,
pubmed-meshheading:16314439-Protein Structure, Tertiary,
pubmed-meshheading:16314439-Cell Proliferation,
pubmed-meshheading:16314439-Autoimmunity,
pubmed-meshheading:16314439-T-Lymphocytes,
pubmed-meshheading:16314439-Killer Cells, Natural,
pubmed-meshheading:16314439-Cytokines,
pubmed-meshheading:16314439-Mice, Knockout
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