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pubmed-article:16313330pubmed:abstractTextChronic allograft nephropathy (CAN), associated with late-allograft dysfunction is caused by alloantigen-dependent and -independent mechanisms, and eventually leads to interstitial fibrosis (ci). Activation of complement cascade is considered to be a poor prognostic marker of graft survival. This study was designed to examine the relationship between the expression of C4d and heat-shock protein 47 (HSP47, a collagen-specific chaperone) in the development of interstitial fibroproliferative lesions in CAN.lld:pubmed
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pubmed-article:16313330pubmed:articleTitleInterstitial expression of heat-shock protein 47 correlates with capillary deposition of complement split product C4d in chronic allograft nephropathy.lld:pubmed
pubmed-article:16313330pubmed:affiliationDepartment of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.lld:pubmed
pubmed-article:16313330pubmed:publicationTypeJournal Articlelld:pubmed