Linked Life Data

16311015

Source:http://linkedlifedata.com/resource/pubmed/id/16311015

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-1-2
pubmed:abstractText
SynCAM 1 (synaptic cell adhesion molecule 1, alternatively named Tslc1 and nectin-like protein 3) belongs to the immunoglobulin superfamily and is an adhesion molecule that operates in a variety of important contexts. Exemplary are its roles in adhesion at synapses in the central nervous system and as tumor suppressor. Here, I describe a family of genes homologous to SynCAM 1 comprising four genes found solely in vertebrates. All SynCAM genes encode proteins with three immunoglobulin-like domains of the V-set, C1-set, and I-set subclasses. Comparison of genomic with cDNA sequences provides their exon-intron structure. Alternative splicing generates isoforms of SynCAM proteins, and diverse SynCAM 1 and 2 isoforms are created in an extracellular region rich in predicted O-glycosylation sites. Protein interaction motifs in the cytosolic sequence are highly conserved among all four SynCAM proteins, indicating their critical functional role. These findings aim to facilitate the understanding of SynCAM genes and provide the framework to examine the physiological functions of this family of vertebrate-specific adhesion molecules.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0888-7543
pubmed:author
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
139-50
pubmed:dateRevised
2011-5-2
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Bioinformatic characterization of the SynCAM family of immunoglobulin-like domain-containing adhesion molecules.
pubmed:affiliation
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA. thomas.biederer@yale.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural